Trial reportJournal of the American Heart Association2013
Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results.
Trial report in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01710072 (Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- The effect of aspirin on inflammatory response in intracranial aneurysm: a systematic review.Inflammopharmacology · 2025Pooled it
- Prevalence, predictors and prognosis of incidental intracranial aneurysms in patients with suspected TIA and minor stroke: a population-based study and systematic review.Journal of neurology, neurosurgery, and psychiatry · 2021Pooled it
- The Role of Aspirin in the Management of Intracranial Aneurysms: A Systematic Review and Meta-Analyses.Frontiers in neurology · 2021Pooled it
- Body pigmentation as a risk factor for the formation of intracranial aneurysms.BioMed research international · 2014Trial
- Achievement and Future Prospectives from Translational Research Targeting Intracranial Aneurysm.Neurologia medico-chirurgica · 2026Review
- Causal relationships between alterations in shear stress-related genes and aneurysmal subarachnoid hemorrhage.Orphanet journal of rare diseases · 2025Article
- The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture.Journal of clinical medicine · 2024Review
- Aspirin treatment for unruptured intracranial aneurysms: Focusing on its anti-inflammatory role.Heliyon · 2024Review
- Peripheral macrophages in the development and progression of structural cerebrovascular pathologies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Intracranial aneurysm rupture risk in northern China: a retrospective case-control study.Quantitative imaging in medicine and surgery · 2024Article
- The Role of the NF-kB Pathway in Intracranial Aneurysms.Brain sciences · 2023Review
- Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm.Scientific reports · 2023Article
- European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms.European stroke journal · 2022Article
- Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits.Journal of neurointerventional surgery · 2022Article
- Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations.Frontiers in neurology · 2022Article
- Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms.Frontiers in immunology · 2022Article
- Unruptured cerebral aneurysms in elderly patients: key challenges and management.Annals of medicine · 2021Review
- Decreased contrast enhancement on high-resolution vessel wall imaging of unruptured intracranial aneurysms in patients taking aspirin.Journal of neurosurgery · 2021Article
- Vascular Macrophages as Therapeutic Targets to Treat Intracranial Aneurysms.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundInflammatory cells and molecules may play a critical role in formation and rupture of cerebral aneurysms. Recently, an epidemiologic study reported that acetylsalicylic acid (ASA) decreases the risk of aneurysm rupture. The goal of this study was to determine the effects of ASA on inflammatory cells and molecules in the walls of human cerebral aneurysms, using radiographic and histological techniques. METHODS AND
resultsEleven prospectively enrolled patients harboring unruptured intracranial aneurysms were randomized into an ASA-treated (81 mg daily) group (n=6) and an untreated (control) group (n=5). Aneurysms were imaged at baseline using ferumoxytol-enhanced MRI to estimate uptake by macrophages. After 3 months, patients were reimaged before undergoing microsurgical clipping. Aneurysm tissues were collected for immunostaining with monoclonal antibodies for cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and macrophages. A decrease in signal intensity on ferumoxytol-enhanced MRI was observed after 3 months of ASA treatment. Expression of COX-2 (but not COX-1), mPGES-1, and macrophages was lower in the ASA group than in the control group.
conclusionsThis study provides preliminary radiographical and histological evidence that ASA may attenuate the inflammatory process in the walls of human cerebral aneurysms. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01710072.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.