ArticleJournal of biomedical optics2013
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring.Journal of biomedical optics · 2023Article
- Review
- Modeling and Synthesis of Breast Cancer Optical Property Signatures With Generative Models.IEEE transactions on medical imaging · 2021Article
- Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.Biomedical optics express · 2021Article
- Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography.Journal of biomedical optics · 2020Article
- First experience with spatial frequency domain imaging and red-light excitation of protoporphyrin IX fluorescence during tumor resection.Biomedical optics express · 2020Article
- Wide-field optical spectroscopy system integrating reflectance and spatial frequency domain imaging to measure attenuation-corrected intrinsic tissue fluorescence in radical prostatectomy specimens.Biomedical optics express · 2020Article
- Spatial frequency domain imaging in 2019: principles, applications, and perspectives.Journal of biomedical optics · 2019Review
- Low-cost compact multispectral spatial frequency domain imaging prototype for tissue characterization.Biomedical optics express · 2018Article
- Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.Journal of biomedical optics · 2018Article
- Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018Review
- Quantitative multispectralBiomedical optics express · 2018Article
- Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection.Journal of biomedical optics · 2017Article
- Evaluation of breast tissue with confocal strip-mosaicking microscopy: a test approach emulating pathology-like examination.Journal of biomedical optics · 2017Article
- Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.Journal of biomedical optics · 2017Article
- Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model.Biomedical optics express · 2016Article
- Characterizing optical properties and spatial heterogeneity of human ovarian tissue using spatial frequency domain imaging.Journal of biomedical optics · 2016Article
- In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy.Journal of biomedical optics · 2016Article
- Noninvasive assessment of hemodynamic and brain metabolism parameters following closed head injury in a mouse model by comparative diffuse optical reflectance approaches.Neurophotonics · 2016Article
- Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.Biomedical optics express · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The feasibility of spatial frequency domain imaging (SFDI) for breast surgical margin assessment was evaluated in tissue-simulating phantoms and in fully intact lumpectomy specimens at the time of surgery. Phantom data was evaluated according to contrast-detail resolution, quantitative accuracy and model-data goodness of fit, where optical parameters were estimated by minimizing the residual sum of squares between the measured modulation amplitude and its solutions, modeled according to diffusion and scaled-Monte Carlo simulations. In contrast-detail phantoms, a 1.25-mm-diameter surface inclusion was detectable for scattering contrast >28%; a fraction of this scattering contrast (7%) was detectable for a 10 mm surface inclusion and at least 33% scattering contrast was detected up to 1.5 mm below the phantom surface, a probing depth relevant to breast surgical margin assessment. Recovered hemoglobin concentrations were insensitive to changes in scattering, except for overestimation at visible wavelengths for total hemoglobin concentrations <15 μM. The scattering amplitude increased linearly with scattering concentration, but the scattering slope depended on both the particle size and number density. Goodness of fit was comparable for the diffusion and scaled-Monte Carlo models of transport in spatially modulated, near-infrared reflectance acquired from 47 lumpectomy tissues, but recovered absorption parameters varied more linearly with expected hemoglobin concentration in liquid phantoms for the scaled-Monte Carlo forward model. SFDI could potentially reduce the high secondary excision rate associated with breast conserving surgery; its clinical translation further requires reduced image reconstruction time and smart inking strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.