ArticleNature genetics2013
Genomics of Loa loa, a Wolbachia-free filarial parasite of humans.
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
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Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What helminth genomes have taught us about parasite evolution.Parasitology · 2015Pooled it
- Molecular Epidemiology of Skin-Dwelling Filariae and Risk Factors for Mansonella streptocerca Infection, Gabon.Emerging infectious diseases · 2026Article
- Understanding Calabar swellings: Assessing subcutaneous loiasis using ultrasound.PLoS neglected tropical diseases · 2026Article
- Whole-genome sequence of a female Loa loa adult worm from Cameroon.BMC research notes · 2026Article
- Genotypic Analysis ofInternational journal of molecular sciences · 2026Article
- Ghosts of symbionts past: the hidden history of the dynamic association between filarial nematodes and their Wolbachia endosymbionts.G3 (Bethesda, Md.) · 2025Article
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- Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome biology and evolution · 2023Article
- Longitudinal study of cross-reactive antigenemia in individuals with highFrontiers in parasitology · 2023Article
- The improved genome of the nematode Parapristionchus giblindavisi provides insights into lineage-specific gene family evolution.G3 (Bethesda, Md.) · 2022Article
- A highly divergentProceedings. Biological sciences · 2022Article
- The Human FilariaResearch and reports in tropical medicine · 2022Review
- Bacteriome Diversity of Blackflies' Gut and Association withPathogens (Basel, Switzerland) · 2021Article
- The evolution of the metazoan Toll receptor family and its expression during protostome development.BMC ecology and evolution · 2021Article
- X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.PLoS neglected tropical diseases · 2021Article
- Wolbachia: endosymbiont of onchocercid nematodes and their vectors.Parasites & vectors · 2021Review
- The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes.BMC genomics · 2021Article
- The genome sequence of the Australian filarial nematode,Wellcome open research · 2021Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
Loa loa, the African eyeworm, is a major filarial pathogen of humans. Unlike most filariae, L. loa does not contain the obligate intracellular Wolbachia endosymbiont. We describe the 91.4-Mb genome of L. loa and that of the related filarial parasite Wuchereria bancrofti and predict 14,907 L. loa genes on the basis of microfilarial RNA sequencing. By comparing these genomes to that of another filarial parasite, Brugia malayi, and to those of several other nematodes, we demonstrate synteny among filariae but not with nonparasitic nematodes. The L. loa genome encodes many immunologically relevant genes, as well as protein kinases targeted by drugs currently approved for use in humans. Despite lacking Wolbachia, L. loa shows no new metabolic synthesis or transport capabilities compared to other filariae. These results suggest that the role of Wolbachia in filarial biology is more subtle than previously thought and reveal marked differences between parasitic and nonparasitic nematodes.
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