Trial reportNature neuroscience2013
Dopamine restores reward prediction errors in old age.
Trial report in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 139 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
139 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- Reinforcement learning models and their neural correlates: An activation likelihood estimation meta-analysis.Cognitive, affective & behavioral neuroscience · 2015Pooled it
- L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others.Psychopharmacology · 2024Trial
- Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication.Molecular psychiatry · 2023Trial
- Trial
- Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone.Psychological medicine · 2019Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- The effect of single-dose methylphenidate on the rate of error-driven learning in healthy males: a randomized controlled trial.Psychopharmacology · 2017Trial
- Trial
- Dopaminergic Enhancement of Striatal Response to Reward in Major Depression.The American journal of psychiatry · 2017Trial
- Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Behavioral and Neural Signatures of Reduced Updating of Alternative Options in Alcohol-Dependent Patients during Flexible Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- Dopamine Increases a Value-Independent Gambling Propensity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson's disease with clinical and neuroimaging measures.Human brain mapping · 2016Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Amphetamine modulates brain signal variability and working memory in younger and older adults.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Dopamine modulates the neural representation of subjective value of food in hungry subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Mind matters: placebo enhances reward learning in Parkinson's disease.Nature neuroscience · 2014Trial
- Role of dopamine D2 receptors in human reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens.Psychopharmacology · 2014Trial
- Trial
79 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value, resulting in an incomplete reward prediction error (RPE) signal in the nucleus accumbens, a brain region that receives rich input projections from substantia nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural connectivity between SN/VTA and striatum, measured by diffusion tensor imaging, was tightly coupled to inter-individual differences in the expression of this expected reward value signal. The dopamine precursor levodopa (L-DOPA) increased the task-based learning rate and task performance in some older adults to the level of young adults. This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.