SynthesisPlant physiology2013
Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.
Synthesis in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
120 citing papers in PubMed, 3 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- Meta-analysis and meta-regression of transcriptomic responses to water stress in Arabidopsis.The Plant journal : for cell and molecular biology · 2016Pooled it
- Comprehensive meta-analysis, co-expression, and miRNA nested network analysis identifies gene candidates in citrus against Huanglongbing disease.BMC plant biology · 2015Pooled it
- Identification of conserved drought-adaptive genes using a cross-species meta-analysis approach.BMC plant biology · 2015Pooled it
- Context matters: coordinated transcriptional regulation and root plasticity under multinutrient conditions.The New phytologist · 2026Article
- Cytokinin receptor AHK3 influences leaf size by modulating trans-zeatin-type cytokinin levels in xylem.Plant & cell physiology · 2026Article
- Plant hormone and peptide signaling converge in the genetic network regulating cambium activation in Arabidopsis roots.The Plant cell · 2026Article
- Rational Modulation of Plant Root Development Using Engineered Cytokinin Regulators.ACS synthetic biology · 2025Article
- Exploring the Cytokinin Profile ofMetabolites · 2025Article
- Cytokinin depends on GA biosynthesis and signaling to regulate different aspects of vegetative phase change in Arabidopsis.Nature communications · 2025Article
- Conserved stress-responsive genes involved in the early development of Euterpe Edulis.Scientific reports · 2025Article
- Identification of a Specific Role of Dihydrozeatin in the Regulation of the Cell Differentiation Activity inPlants (Basel, Switzerland) · 2025Article
- Crosstalk among plant hormone regulates the root development.Plant signaling & behavior · 2024Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- Sulfate Availability and Hormonal Signaling in the Coordination of Plant Growth and Development.International journal of molecular sciences · 2024Review
- CRISPR/Cas9-mediated mutations of FANTASTIC FOUR gene family for creating early flowering mutants in tomato.Plant biotechnology journal · 2024Article
- Regulation of chloroplast biogenesis, development, and signaling by endogenous and exogenous cues.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Hormone-regulated expansins: Expression, localization, and cell wall biomechanics in Arabidopsis root growth.Plant physiology · 2023Article
- Genome-Wide Identification of the RR Gene Family and Its Expression Analysis in Response to TDZ Induction inPlants (Basel, Switzerland) · 2023Article
- Nitrate, Auxin and Cytokinin-A Trio to Tango.Cells · 2023Review
- Plant microbiota controls an alternative root branching regulatory mechanism in plants.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Cytokinins are N(6)-substituted adenine derivatives that play diverse roles in plant growth and development. We sought to define a robust set of genes regulated by cytokinin as well as to query the response of genes not represented on microarrays. To this end, we performed a meta-analysis of microarray data from a variety of cytokinin-treated samples and used RNA-seq to examine cytokinin-regulated gene expression in Arabidopsis (Arabidopsis thaliana). Microarray meta-analysis using 13 microarray experiments combined with empirically defined filtering criteria identified a set of 226 genes differentially regulated by cytokinin, a subset of which has previously been validated by other methods. RNA-seq validated about 73% of the up-regulated genes identified by this meta-analysis. In silico promoter analysis indicated an overrepresentation of type-B Arabidopsis response regulator binding elements, consistent with the role of type-B Arabidopsis response regulators as primary mediators of cytokinin-responsive gene expression. RNA-seq analysis identified 73 cytokinin-regulated genes that were not represented on the ATH1 microarray. Representative genes were verified using quantitative reverse transcription-polymerase chain reaction and NanoString analysis. Analysis of the genes identified reveals a substantial effect of cytokinin on genes encoding proteins involved in secondary metabolism, particularly those acting in flavonoid and phenylpropanoid biosynthesis, as well as in the regulation of redox state of the cell, particularly a set of glutaredoxin genes. Novel splicing events were found in members of some gene families that are known to play a role in cytokinin signaling or metabolism. The genes identified in this analysis represent a robust set of cytokinin-responsive genes that are useful in the analysis of cytokinin function in plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.