ReviewTranslational stroke research2013
Hurdles to clear before clinical translation of ischemic postconditioning against stroke.
Review in Translational stroke research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral protection by remote ischemic post-conditioning in patients with ischemic stroke: A systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2022Pooled it
- Trial
- Direct Ischemic Postconditioning Following Stroke Thrombectomy: A Promising Therapy for Reperfusion Injury.Neuroscience bulletin · 2024Article
- Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8.Translational stroke research · 2024Article
- Remote Ischemic Conditioning May Improve Disability and Cognition After Acute Ischemic Stroke: A Pilot Randomized Clinical Trial.Frontiers in neurology · 2021Article
- Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke.Journal of cerebrovascular and endovascular neurosurgery · 2018Article
- Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?Advances in experimental medicine and biology · 2016Article
- New horizons for newborn brain protection: enhancing endogenous neuroprotection.Archives of disease in childhood. Fetal and neonatal edition · 2015Review
- Remote limb ischemic conditioning enhances motor learning in healthy humans.Journal of neurophysiology · 2015Article
- Beyond BOLD: optimizing functional imaging in stroke populations.Human brain mapping · 2015Review
- Full steam ahead with remote ischemic conditioning for stroke.Translational stroke research · 2014Article
- Article
- Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats.Journal of neurochemistry · 2013Article
- Using hormetic strategies to improve ischemic preconditioning and postconditioning against stroke.International journal of physiology, pathophysiology and pharmacology · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Ischemic postconditioning has been established for its protective effects against stroke in animal models. It is performed after post-stroke reperfusion and refers to a series of induced ischemia or a single brief one. This review article addresses major hurdles in clinical translation of ischemic postconditioning to stroke patients, including potential hazards, the lack of well-defined protective paradigms, and the paucity of deeply-understood protective mechanisms. A hormetic model, often used in toxicology to describe a dose-dependent response to a toxic agent, is suggested to study both beneficial and detrimental effects of ischemic postconditioning. Experimental strategies are discussed, including how to define the hazards of ischemic (homologous) postconditioning and the possibility of employing non-ischemic (heterologous) postconditioning to facilitate clinical translation. This review concludes that a more detailed assessment of ischemic postconditioning and studies of a broad range of heterologous postconditioning models are warranted for future clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.