ArticleMedicina oral, patologia oral y cirugia bucal2013
Preventing root caries development under oral biofilm challenge in an artificial mouth.
Article in Medicina oral, patologia oral y cirugia bucal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Trial
- Dental Restorative Materials for Elderly Populations.Polymers · 2021Review
- Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems.Microorganisms · 2021Review
- Root caries prevention via sodium fluoride, chlorhexidine and silver diamine fluoride in vitro.Odontology · 2018Article
- Arrest of Root Carious Lesions via Sodium Fluoride, Chlorhexidine and Silver Diamine Fluoride In Vitro.Materials (Basel, Switzerland) · 2017Article
- Inhibition of Cariogenic Plaque Formation on Root Surface with Polydopamine-Induced-Polyethylene Glycol Coating.Materials (Basel, Switzerland) · 2016Article
- Experimental Models of Oral Biofilms Developed on Inert Substrates: A Review of the Literature.BioMed research international · 2016Review
- A biofilm cariogenic challenge model for dentin demineralization and dentin bonding analysis.Clinical oral investigations · 2015Article
- The virulence of Streptococcus mutans and the ability to form biofilms.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries.Annals of clinical microbiology and antimicrobials · 2013Article
- The influence of Brazilian plant extracts on Streptococcus mutans biofilm.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the preventive effects of chlorhexidine against root caries under oral biofilm in an artificial mouth. STUDY
designSixteen human tooth-root disks were inoculated with a salivary sample that was produced by mixing the unstimulated saliva of three adults who had no untreated caries. The disks were incubated in an artificial mouth fed with a 5% sucrose solution three times daily for one week. Eight disks received a twice daily rinse of 0.12% chlorhexidine (test group). The other eight disks were rinsed in distilled water (control). The biofilm was then studied with three techniques: colony forming unit (CFU) counting, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The changes in the chemical structure of the root surface were studied using Fourier transform infra-Red spectroscopy. Type-I collagen and proteoglycans on the root surface were quantified using immunocytochemical staining.
resultsThe log CFU for the test and control groups were 4.21 and 8.27, respectively (p<0.001). The CFU count of Streptococci and Lactobacilli were negligible. Both the SEM and the CLSM showed suppressed bacteria growth in the test group. The log [amide-I: HPO(4)(2-)] of the test and control groups were 1.11 and 1.93, respectively (p=0.02). The mean counts of sound type-I collagen in the test and control groups were 16.8/μm(2) and 13.0/μm(2), respectively (p<0.001), whereas the mean counts of intact proteoglycans were 5.6/μm(2) and 3.5/μm(2), respectively (P<0.001).
conclusionsChlorhexidine suppressed the growth of selected cariogenic bacteria in oral biofilm on the root surface and thus protected tooth-root from cariogenic challenge.
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What OpenQuestion holds
Registered trials
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