Evidence map›Paper›PMID 23524348›Full record

ArticleOncoimmunology2013

Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes.

Adam W Mailloux, Pearlie K Epling-Burnette

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Bone Marrow Immunity and Myelodysplasia.Frontiers in oncology · 2016
    Review
  9. The inflammatory microenvironment in MDS.Cellular and molecular life sciences : CMLS · 2015
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Adam W MaillouxImmunology Program; H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA.
Pearlie K Epling-Burnette
James A. Haley Veterans' Hospital · USUniversity of Tampa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.

Indexed as

immune escapeimmunoeditingleukemiamyelodysplastic syndromeregulatory T cells

Identifiers

PMID23524348
PMCPMC3601152
OpenAlexW1987204621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.