Trial reportContemporary clinical trials2013
Can weight loss improve migraine headaches in obese women? Rationale and design of the Women's Health and Migraine (WHAM) randomized controlled trial.
Trial report in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292936 (Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Remotely-Delivered Behavioral Intervention for Post-Bariatric Surgery Weight Regain
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Trial
- The Association of Changes in Pain Acceptance and Headache-Related Disability.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial.Obesity (Silver Spring, Md.) · 2018Trial
- Objectively measured physical activity in obese women with and without migraine.Cephalalgia : an international journal of headache · 2015Trial
- Applying a biopsychosocial model to migraine: rationale and clinical implications.The journal of headache and pain · 2022Review
- Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.Clinical nutrition research · 2021Article
- Associations between lifestyle intervention-related changes in dietary targets and migraine headaches among women in the Women's Health and Migraine (WHAM) randomized controlled trial.Obesity science & practice · 2020Article
- Lifestyle Modifications to Help Prevent Headache at a Developmental Age.Frontiers in neurology · 2020Review
- Adherence to Behavioral Therapy for Migraine: Knowledge to Date, Mechanisms for Assessing Adherence, and Methods for Improving Adherence.Current pain and headache reports · 2019Review
- Body Mass Index and Primary Headache: A Hospital-Based Study in China.BioMed research international · 2019Article
- Pain worsening with physical activity during migraine attacks in women with overweight/obesity: A prospective evaluation of frequency, consistency, and correlates.Cephalalgia : an international journal of headache · 2018Article
- Association between Body Mass Index and Migraine: A Survey of Adult Population in China.Behavioural neurology · 2018Article
- Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity.The journal of headache and pain · 2017Article
- Complementary and Integrative Medicine for Neurologic Conditions.The Medical clinics of North America · 2017Review
- Association Between Obesity and Migraine in Women.Current pain and headache reports · 2017Review
- Treatment Update of Chronic Migraine.Current pain and headache reports · 2017Review
- Importance of Pain Acceptance in Relation to Headache Disability and Pain Interference in Women With Migraine and Overweight/Obesity.Headache · 2017Article
- Sexual Dysfunction in Women With Migraine and Overweight/Obesity: Relative Frequency and Association With Migraine Severity.Headache · 2017Article
- Behavioral Weight Loss Treatments for Individuals with Migraine and Obesity.Current pain and headache reports · 2016Review
- Emerging behavioral treatments for migraine.Current pain and headache reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundResearch demonstrates a link between migraine and obesity. Obesity increases the risk of frequent migraines and is associated with migraine prevalence among reproductive-aged women. These findings are substantiated by several plausible mechanisms and emerging evidence of migraine improvements after surgical and non-surgical weight loss. However, no previous study has examined the effect of weight loss on migraine within a treatment-controlled framework. The WHAM trial is an RCT to test the efficacy of behavioral weight loss as a treatment for migraine. STUDY
designOverweight/obese women (n=140; BMI=25.0-49.9 kg/m(2)) who meet international diagnostic criteria for migraine and record ≥3 migraines and 4-20 migraine days using a smartphone-based headache diary during a 4-week baseline period, will be randomly assigned to 4 months of either group-based behavioral weight loss (intervention) or migraine education (control). Intervention participants will be taught strategies to increase physical activity and consume fewer calories in order to lose weight. Control participants will receive general education on migraine symptoms/triggers and various treatment approaches. Both groups will use smartphones to record their headaches for 4 weeks at baseline, after the 16-week treatment period, and at the end of a 16-week follow-up period. Changes in weight and other potential physiological (inflammation), psychological (depression), and behavioral (diet and physical activity) mediators of the intervention effect will also be assessed.
conclusionThe WHAM trial will evaluate the efficacy of a standardized behavioral weight loss intervention for reducing migraine frequency, and the extent to which weight loss and other potential mediators account for intervention effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.