ArticleBiochimica et biophysica acta2014
Global analysis of phosphorylation networks in humans.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- KEA3: improved kinase enrichment analysis via data integration.Nucleic acids research · 2021Article
- The integrated stress response: From mechanism to disease.Science (New York, N.Y.) · 2020Review
- Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo.Cell systems · 2019Article
- Next-Generation Genome-Scale Models Incorporating Multilevel 'Omics Data: From Yeast to Human.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Signaling Architectures that Transmit Unidirectional Information Despite Retroactivity.Biophysical journal · 2017Article
- Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A Human Proteome Array Approach to Identifying Key Host Proteins Targeted byMolecular & cellular proteomics : MCP · 2017Article
- K-BILDS: A Kinase Substrate Discovery Tool.Chembiochem : a European journal of chemical biology · 2017Article
- Quantifying Kinase-Specific Phosphorylation Stoichiometry Using Stable Isotope Labeling In a Reverse In-Gel Kinase Assay.Analytical chemistry · 2016Article
- Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction.PLoS computational biology · 2015Article
- Toward a systems-level view of dynamic phosphorylation networks.Frontiers in genetics · 2014Review
- PhosphoNetworks: a database for human phosphorylation networks.Bioinformatics (Oxford, England) · 2014Article
- Construction of human activity-based phosphorylation networks.Molecular systems biology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Phosphorylation-mediated signaling plays a crucial role in nearly every aspect of cellular physiology. A recent study based on protein microarray experiments identified a large number of kinase-substrate relationships (KSRs), and built a comprehensive and reliable phosphorylation network in humans. Analysis of this network, in conjunction with additional resources, revealed several key features. First, comparison of the human and yeast phosphorylation networks uncovered an evolutionarily conserved signaling backbone dominated by kinase-to-kinase relationships. Second, although most of the KSRs themselves are not conserved, the functions enriched in the substrates for a given kinase are often conserved. Third, the prevalence of kinase-transcription factor regulatory modules suggests that phosphorylation and transcriptional regulatory networks are inherently wired together to form integrated regulatory circuits. Overall, the phosphorylation networks described in this work promise to offer new insights into the properties of kinase signaling pathways, at both the global and the protein levels. This article is part of a Special Issue entitled: Computational Proteomics, Systems Biology & Clinical Implications. Guest Editor: Yudong Cai.
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Registered trials
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