ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2013
Increased risk for irritable bowel syndrome after acute diverticulitis.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02003807 (Incidence and Predictive Factor of Irritable Bowel Syndrome After Acute Diverticulitis in Korea), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence and Predictive Factor of Irritable Bowel Syndrome After Acute Diverticulitis in Korea
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Long-term outcomes in recurrent diverticulitis: a systematic review of treatment strategies and recurrence rates.International journal of colorectal disease · 2026Pooled it
- Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction.Nature reviews. Gastroenterology & hepatology · 2025Review
- Rifaximin in diverticulosis and diverticular disease: a national survey among Italian gastroenterologists and general practitioners.Internal and emergency medicine · 2024Article
- Site and duration of abdominal pain discriminate symptomatic uncomplicated diverticular disease from previous diverticulitis patients.Internal and emergency medicine · 2024Observational
- Diverticular disease: update on pathophysiology, classification and management.Frontline gastroenterology · 2024Review
- Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Protective effects of amoxicillin and probiotics on colon disorders in an experimental model of acute diverticulitis disease.Inflammopharmacology · 2022Article
- Colonic Diverticulosis Is Not Associated With Painful Abdominal Symptoms in a US Population.Gastro hep advances · 2022Article
- Health-related quality of life and functional disorders after diverticular surgery.Therapeutic advances in gastroenterology · 2021Review
- Colonic diverticular disease.Nature reviews. Disease primers · 2020Review
- Etiopathogenetic Mechanisms in Diverticular Disease of the Colon.Cellular and molecular gastroenterology and hepatology · 2020Review
- Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.Frontiers in psychiatry · 2020Review
- Mesalamine (5-ASA) for the prevention of recurrent diverticulitis (Review).Techniques in coloproctology · 2019Review
- Epidemiology, Pathophysiology, and Treatment of Diverticulitis.Gastroenterology · 2019Review
- Severity of Diverticulitis Does Not Influence Abdominal Complaints during Long-Term Follow-Up.Digestive surgery · 2019Article
- Recurrent Acute Diverticulitis: When to Operate?Inflammatory intestinal diseases · 2018Review
- Abundance ofWorld journal of gastrointestinal pathophysiology · 2018Article
- Recent advances in understanding and managing diverticulitis.F1000Research · 2018Review
- High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment.Therapeutic advances in gastroenterology · 2018Article
- Progress and challenges in the management of diverticular disease: which treatment?Therapeutic advances in gastroenterology · 2018Review
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsIndividuals with diverticulosis frequently also have irritable bowel syndrome (IBS), but there are no longitudinal data to associate acute diverticulitis with subsequent IBS, functional bowel disorders, or related emotional distress. In patients with postinfectious IBS, gastrointestinal disorders cause long-term symptoms, so we investigated whether diverticulitis might lead to IBS. We compared the incidence of IBS and functional bowel and related affective disorders among patients with diverticulitis.
methodsWe performed a retrospective study of patients followed up for an average of 6.3 years at a Veteran's Administration medical center. Patients with diverticulitis were identified based on International Classification of Diseases, 9th revision codes, selected for the analysis based on chart review (cases, n = 1102), and matched with patients without diverticulosis (controls, n = 1102). We excluded patients with prior IBS, functional bowel, or mood disorders. We then identified patients who were diagnosed with IBS or functional bowel disorders after the diverticulitis attack, and controls who developed these disorders during the study period. We also collected information on mood disorders, analyzed survival times, and calculated adjusted hazard ratios.
resultsCases were 4.7-fold more likely to be diagnosed later with IBS (95% confidence interval [CI], 1.6-14.0; P = .006), 2.4-fold more likely to be diagnosed later with a functional bowel disorder (95% CI, 1.6-3.6; P < .001), and 2.2-fold more likely to develop a mood disorder (CI, 1.4-3.5; P < .001) than controls.
conclusionsPatients with diverticulitis could be at risk for later development of IBS and functional bowel disorders. We propose calling this disorder postdiverticulitis IBS. Diverticulitis appears to predispose patients to long-term gastrointestinal and emotional symptoms after resolution of inflammation; in this way, postdiverticulitis IBS is similar to postinfectious IBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.