Evidence map›Paper›PMID 23523988›Full record

Trial reportJournal of anxiety disorders2013

Treating individuals with social anxiety disorder and at-risk drinking: phasing in a brief alcohol intervention following paroxetine.

Sarah W Book, Suzanne E Thomas, Joshua P Smith, Patrick K Randall, Matt G Kushner, Gail A Bernstein, Sheila M Specker, Peter M Miller, Carrie L Randall

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of anxiety disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah W BookCharleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, United States. booksw@musc.edu
Suzanne E Thomas
Joshua P Smith
Patrick K Randall
Matt G Kushner
Gail A Bernstein
Sheila M Specker
Peter M Miller
Carrie L Randall

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWARD C. BECKER · 1996 to 2026
$46.8M
Dismantling the Components and Dosing of CBT for Co-Occurring DisordersR01AA015069 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KUSHNER, MATT G · 2005 to 2018
$3.8M
Phased Treatment for Social Anxiety and Hazardous DrinkingR01AA013379 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BOOK, SARAH W. · 2002 to 2011
$3.3M
Applying Latent Variable Modeling to Cormorbidity Treatment ResearchK02AA017886 · NIAAA · UNIVERSITY OF MINNESOTA · PI KUSHNER, MATT G · 2009 to 2013
$573k
NIAAA NIH HHS K02 AA017886NIAAA NIH HHS K02AA017886NIAAA NIH HHS P50 AA010761NIAAA NIH HHS P50AA010761NIAAA NIH HHS R01 AA013379NIAAA NIH HHS R01AA013379NIAAA NIH HHS R01 AA015069
6 · The paper itself

Abstract

Paroxetine alone is not sufficient to decrease alcohol use in socially anxious alcoholics seeking anxiety treatment. We tested the hypothesis that adding a brief-alcohol-intervention (BI) to paroxetine would decrease alcohol use. All subjects (N=83) had a diagnosis of social anxiety disorder, endorsed drinking to cope with anxiety, were NIAAA-defined at-risk drinkers, and were randomized to either paroxetine alone, or paroxetine plus BI. Both groups showed significant improvement in both social anxiety severity (F(5,83)=61.5, p<0.0001) and drinking to cope (e.g. F(4,79)=23, p<0.0001) and these two constructs correlated with each other (B=3.39, SE=0.696, t(71)=4.88, p<0.001). BI was not effective at decreasing alcohol use (e.g. no main effect of group, all p values >0.3). Paroxetine decreased social anxiety severity in the face of heavy drinking and decreasing the anxiety was related to a concurrent decrease in coping related drinking. BI was not effective at decreasing drinking or drinking to cope.

Indexed as

Adaptation, PsychologicalAdultAlcohol DrinkingAntidepressive Agents, Second-GenerationAnxietyAnxiety DisordersCombined Modality TherapyDiagnosis, Dual (Psychiatry)FemaleHumansMaleParoxetinePhobic DisordersSocial Behavior DisordersAntidepressive Agents, Second-GenerationParoxetine

Identifiers

PMID23523988
PMCPMC3756669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.