Evidence map›Paper›PMID 23523921›Full record

ArticleFEBS letters2013

Identification and characterization of the nano-sized vesicles released by muscle cells.

Daniele P Romancino, Gaetano Paterniti, Yvan Campos, Angela De Luca, Valentina Di Felice, Alessandra d'Azzo, Antonella Bongiovanni

Abstract read
In one paragraph

Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Roles of Exosomes in Chronic Rhinosinusitis: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Review
  4. Mitochondrial proteostasis regulated by CRL5Communications biology · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Extracellular vesicles as personalized medicine.Molecular aspects of medicine · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. The Cellular and Molecular Signature of ALS in Muscle.Journal of personalized medicine · 2022
    Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniele P RomancinoInstitute of Biomedicine and Molecular Immunology A. Monroy (IBIM), National Research Council (CNR), Palermo, Italy.
Gaetano Paterniti
Yvan Campos
Angela De Luca
Valentina Di Felice
Alessandra d'Azzo
Antonella Bongiovanni

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Specificity and Activity of Ozz-E3 During MyogenesisR01AR049867 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI D'AZZO, ALESSANDRA · 2004 to 2008
$1.2M
NCI NIH HHS CA021765NCI NIH HHS P30 CA021765NIAMS NIH HHS AR049867NIAMS NIH HHS R01 AR049867
6 · The paper itself

Abstract

Several cell types secrete small membranous vesicles that contain cell-specific collections of proteins, lipids, and genetic material. The function of these vesicles is to allow cell-to-cell signaling and the horizontal transfer of their cargo molecules. Here, we demonstrate that muscle cells secrete nano-sized vesicles and that their release increases during muscle differentiation. Analysis of these nanovesicles allowed us to characterize them as exosome-like particles and to define the potential role of the multifunctional protein Alix in their biogenesis.

Indexed as

NanostructuresAnimalsCalcium-Binding ProteinsCell DifferentiationCell LineCell MembraneExosomesMiceMuscle CellsCalcium-Binding ProteinsPdcd6ip protein, mouse

Identifiers

PMID23523921
PMCPMC4714929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.