ArticleNeuron2013
Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.Neuron · 2026Article
- Article
- Experience reorganizes content-specific memory traces in macaques.Nature neuroscience · 2026Article
- Article
- Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Review
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice.Nature communications · 2025Article
- Origin of visual experience-dependent theta oscillations.Current biology : CB · 2025Article
- Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus.PLoS biology · 2024Article
- Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely moving macaques.Cell reports · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Circuit dynamics of superficial and deep CA1 pyramidal cells and inhibitory cells in freely-moving macaques.bioRxiv : the preprint server for biology · 2024Article
- Wired together, change together: Spike timing modifies transmission in converging assemblies.Science advances · 2024Article
- Analysis of hippocampal synaptic function in a rodent model of early life stress.Wellcome open research · 2024Article
- Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation.Nature communications · 2023Article
- The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
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Abstract
In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goal-oriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of interneurons developed a relationship to new, learning-related assemblies: some interneurons associated their activity with new pyramidal assemblies while some others dissociated from them. These firing associations were explained by changes in the weight of monosynaptic inputs received by interneurons from new pyramidal assemblies, as these predicted the associational changes. Spatial learning thus engages circuit modifications in the hippocampus that incorporate a redistribution of inhibitory activity that might assist in the segregation of competing pyramidal cell assembly patterns in space and time.
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Registered trials
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