Evidence map›Paper›PMID 23523473›Full record

ArticleLeukemia research2013

Patterns of erythropoiesis-stimulating agent use among Medicare beneficiaries with myelodysplastic syndromes and consistency with clinical guidelines.

Amy J Davidoff, Sheila R Weiss, Maria R Baer, Xuehua Ke, Franklin Hendrick, Amer Zeidan, Steven D Gore

Abstract read
In one paragraph

Article in Leukemia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. The Clinical Efficacy of Epoetin Alfa and Darbepoetin Alfa in Patients with Low-Risk or Intermediate-1-Risk Myelodysplastic Syndrome: Retrospective Multi-center Real-Life Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2022
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Assessing Quality of Care for the Myelodysplastic Syndromes.Current hematologic malignancy reports · 2016
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Observational
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amy J DavidoffCenter for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. amy.davidoff@ahrq.hhs.gov
Sheila R Weiss
Maria R Baer
Xuehua Ke
Franklin Hendrick
Amer Zeidan
Steven D Gore

Funding

Targeting Epigenomics in Myeloid NeoplasmsK24CA111717 · NCI · YALE UNIVERSITY · PI GORE, STEVEN D · 2005 to 2015
$1.7M
Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDSRC1CA145831 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI DAVIDOFF, AMY J · 2009 to 2010
$774k
NCI NIH HHS 1RC1CA145831-01NCI NIH HHS 2K24CA111717-06A1NCI NIH HHS K24 CA111717NCI NIH HHS RC1 CA145831
6 · The paper itself

Abstract

Erythropoiesis-stimulating agents (ESA) are used commonly to reduce symptomatic anemia in patients with myelodysplastic syndromes (MDS). We assessed population-based patterns of ESA use relative to treatment guidelines using data from the Surveillance, Epidemiology, and End Results (SEER) registries, with linked Medicare claims providing detailed treatment data from 2001 through 2005. The study found widespread use (62%) of ESA in Medicare beneficiaries with MDS. Similar ESA use rates regardless of risk status, low frequency (45%) of serum erythropoietin determination prior to ESA initiation, and high prevalence (60.4%) of short-duration ESA episodes suggest clinically important discrepancies between actual practice and guideline-recommended therapy.

Indexed as

AdultAgedAged, 80 and overDarbepoetin alfaDrug UtilizationEpoetin AlfaErythropoietinFemaleGuideline AdherenceHematinicsHumansMaleMedicareMiddle AgedMyelodysplastic SyndromesPractice Guidelines as TopicDarbepoetin alfaEpoetin AlfaErythropoietinHematinicsRecombinant Proteins

Identifiers

PMID23523473
PMCPMC3694576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.