ArticleCell reports2013
The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Antisense Oligonucleotide-MediatedAnimals : an open access journal from MDPI · 2026Article
- Reprogramming the inactive X chromosome: dynamics and insights from the germline.Biochemical Society transactions · 2026Review
- Xist condensates: perspectives for therapeutic intervention.Genome biology · 2025Review
- KDM6A facilitates Xist upregulation at the onset of X inactivation.Biology of sex differences · 2025Article
- Orchestrating Asymmetric Expression: Mechanisms behindEpigenomes · 2024Review
- GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers.Nature cell biology · 2023Article
- Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation.Current opinion in genetics & development · 2023Review
- Reply to Galupa et al: Discussing the role of Lppnx in the complexity of the X controlling element, Xce.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A long noncoding RNA influences the choice of the X chromosome to be inactivated.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.Genome biology · 2021Article
- Review
- A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary.Molecular cell · 2020Article
- Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.Genome research · 2019Article
- Recent Advances in Understanding the Reversal of Gene Silencing During X Chromosome Reactivation.Frontiers in cell and developmental biology · 2019Review
- XIST and TSIX: Novel Cancer Immune Biomarkers in PD-L1-Overexpressing Breast Cancer Patients.Frontiers in oncology · 2019Article
- Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males.Cell stem cell · 2018Article
- When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.Cell reports · 2017Article
- Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.International journal of molecular sciences · 2016Article
- Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.Molecular and cellular biology · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
X chromosome inactivation (XCI) is a dynamically regulated developmental process with inactivation and reactivation accompanying the loss and gain of pluripotency, respectively. A functional relationship between pluripotency and lack of XCI has been suggested, whereby pluripotency transcription factors repress the master regulator of XCI, the noncoding transcript Xist, by binding to its first intron (intron 1). To test this model, we have generated intron 1 mutant embryonic stem cells (ESCs) and two independent mouse models. We found that Xist's repression in ESCs, its transcriptional upregulation upon differentiation, and its silencing upon reprogramming to pluripotency are not dependent on intron 1. Although we observed subtle effects of intron 1 deletion on the randomness of XCI and in the absence of the antisense transcript Tsix in differentiating ESCs, these have little relevance in vivo because mutant mice do not deviate from Mendelian ratios of allele transmission. Altogether, our findings demonstrate that intron 1 is dispensable for the developmental dynamics of Xist expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.