ArticleThe Annals of thoracic surgery2013
Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.
Article in The Annals of thoracic surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 31 citations in OpenAlex.
- Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction.Bioengineering (Basel, Switzerland) · 2026Review
- Multiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.Acta biomaterialia · 2024Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Pinocembrin ameliorates arrhythmias in rats with chronic ischaemic heart failure.Annals of medicine · 2021Article
- Ventricular Arrhythmias in Ischemic Cardiomyopathy-New Avenues for Mechanism-Guided Treatment.Cells · 2021Review
- The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart.Scientific reports · 2021Article
- Unraveling the Metabolic Derangements Occurring in Non-infarcted Areas of Pig Hearts With Chronic Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- Exploring cardiac form and function: A length-scale computational biology approach.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Article
- Acellular Extracellular Matrix Bioscaffolds for Cardiac Repair and Regeneration.Frontiers in cell and developmental biology · 2019Review
- Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium.The Annals of thoracic surgery · 2018Article
- Complex electrophysiological remodeling in postinfarction ischemic heart failure.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantitative Proteomics and Immunohistochemistry Reveal Insights into Cellular and Molecular Processes in the Infarct Border Zone One Month after Myocardial Infarction.Journal of proteome research · 2017Article
- Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall.The Annals of thoracic surgery · 2017Article
- Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.Heart failure reviews · 2016Review
- Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.The Journal of thoracic and cardiovascular surgery · 2016Article
- A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging.Journal of biomechanical engineering · 2015Article
- Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.The Annals of thoracic surgery · 2014Article
- Regional wall function before and after acute myocardial infarction; an experimental study in pigs.BMC cardiovascular disorders · 2014Article
- Bioengineered stromal cell-derived factor-1α analogue delivered as an angiogenic therapy significantly restores viscoelastic material properties of infarcted cardiac muscle.Journal of biomechanical engineering · 2014Article
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14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundContractility in the borderzone (BZ) after anteroapical myocardial infarction (MI) is depressed. We tested the hypothesis that BZ contractility is also decreased after posterolateral MI.
methodsFive sheep underwent posterolateral MI. Magnetic resonance imaging (MRI) was performed 2 weeks before and 16 weeks after MI, and left ventricular (LV) volume and regional strain were measured. Finite element (FE) models were constructed, and the systolic material parameter, Tmax, was calculated in the BZ and remote myocardium by minimizing the difference between experimentally measured and calculated LV strain and volume. Sheep were sacrificed 17 weeks after MI, and myocardial muscle fibers were taken from the BZ and remote myocardium. Fibers were chemically demembranated, and isometric developed force, Fmax, was measured at supramaximal [Ca(2+)]. Routine light microscopy was also performed.
resultsThere was no difference in Tmax in the remote myocardium before and 16 weeks after MI. However, there was a large decrease (63.3%, p = 0.005) in Tmax in the BZ when compared with the remote myocardium 16 weeks after MI. In addition, there was a significant reduction of BZ Fmax for all samples (18.9%, p = 0.0067). Myocyte cross-sectional area increased by 61% (p = 0.021) in the BZ, but there was no increase in fibrosis.
conclusionsContractility in the BZ is significantly depressed relative to the remote myocardium after posterolateral MI. The reduction in contractility is due at least in part to a decrease in contractile protein function.
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