ArticleMethods in enzymology2013
Non-motile primary cilia as fluid shear stress mechanosensors.
Article in Methods in enzymology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Cilia in the brain display region-dependent oscillations of length and orientation.PLoS biology · 2025Article
- PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice.Nature communications · 2025Article
- Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition.Scientific reports · 2025Article
- Measuring Calcium Signaling at the Primary Cilia.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Circadian cilia transcriptome in mouse brain across physiological and pathological states.Molecular brain · 2024Article
- LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels.Apoptosis : an international journal on programmed cell death · 2024Article
- Fluid flow to mimic organ function in 3DAPL bioengineering · 2023Review
- Primary cilium-mediated mechanotransduction in cartilage chondrocytes.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Cilia in the Striatum Mediate Timing-Dependent Functions.Molecular neurobiology · 2023Article
- Shear stress induces autophagy in Schlemm's canal cells via primary cilia-mediated SMAD2/3 signaling pathway.Autophagy reports · 2023Article
- Subtype-Selective Positive Modulation of KACS chemical biology · 2022Article
- Review
- Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations.Molecular neurobiology · 2022Article
- Large-scale analysis reveals spatiotemporal circadian patterns of cilia transcriptomes in the primate brain.Journal of neuroscience research · 2021Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- Zebrafish cardiac regeneration-looking beyond cardiomyocytes to a complex microenvironment.Histochemistry and cell biology · 2020Review
- Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells.Biochemical pharmacology · 2020Article
- Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.Developmental biology · 2020Article
- It takes more than two to tango: mechanosignaling of the endothelial surface.Pflugers Archiv : European journal of physiology · 2020Review
- Article
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6 authors.
Funding
Abstract
Primary cilia are sensory organelles that transmit extracellular signals into intracellular biochemical responses. Structural and functional defects in primary cilia are associated with a group of human diseases, known as ciliopathies, with phenotypes ranging from cystic kidney and obesity to blindness and mental retardation. Primary cilia mediate mechano- and chemosensation in many cell types. The mechanosensory function of the primary cilia requires the atypical G-protein-coupled receptor polycystin-1 and the calcium-permeable nonselective cation channel polycystin-2. Mechanical stimulations such as fluid-shear stress of the primary cilia initiate intracellular calcium rise, nitric oxide release, and protein modifications. In this review, we describe a set of protocols for cell culture to promote ciliation, mechanical stimulations of the primary cilia, and measurements of calcium rise and nitric oxide release induced by fluid shear stress.
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