ArticleBiomaterials2013
Effects of silk fibroin fiber incorporation on mechanical properties, endothelial cell colonization and vascularization of PDLLA scaffolds.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Artificial and Bioengineered Therapeutic Options for Corneal Endothelial Disease.Bioengineering (Basel, Switzerland) · 2025Review
- Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK).NPJ Regenerative medicine · 2025Review
- The Application of Regenerated Silk Fibroin in Tissue Repair.Materials (Basel, Switzerland) · 2024Review
- 3D tumor angiogenesis models: recent advances and challenges.Journal of cancer research and clinical oncology · 2021Review
- Silk Fibroin/Spidroin Electrospun Scaffolds for Full-Thickness Skin Wound Healing in Rats.Pharmaceutics · 2021Article
- A Comparative Analysis of the Structure and Biological Properties of Films and Microfibrous Scaffolds Based on Silk Fibroin.Pharmaceutics · 2021Article
- From arteries to capillaries: approaches to engineering human vasculature.Advanced functional materials · 2020Article
- Improving mechanical and antibacterial properties of PMMA via polyblend electrospinning with silk fibroin and polyethyleneimine towards dental applications.Bioactive materials · 2020Article
- Bioactive Silk Hydrogels with Tunable Mechanical Properties.Journal of materials chemistry. B · 2018Article
- Assessment of the characteristics and biocompatibility of gelatin sponge scaffolds prepared by various crosslinking methods.Scientific reports · 2018Article
- Cortical Reshaping and Functional Recovery Induced by Silk Fibroin Hydrogels-Encapsulated Stem Cells Implanted in Stroke Animals.Frontiers in cellular neuroscience · 2018Article
- Processing Techniques and Applications of Silk Hydrogels in Bioengineering.Journal of functional biomaterials · 2016Review
- Silk Biomaterials with Vascularization Capacity.Advanced functional materials · 2016Article
- Three-Dimensional Imaging of the Developing Vasculature within Stem Cell-Seeded Scaffolds Cultured in ovo.Frontiers in physiology · 2016Article
- A mild process to design silk scaffolds with reduced β-sheet structure and various topographies at the nanometer scale.Acta biomaterialia · 2015Article
- Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects.Biomarker insights · 2015Review
- Electrospun scaffolds of silk fibroin and poly(lactide-co-glycolide) for endothelial cell growth.Journal of materials science. Materials in medicine · 2015Article
- Chitosan-based scaffolds for bone tissue engineering.Journal of materials chemistry. B · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Attainment of functional vascularization of engineered constructs is one of the fundamental challenges of tissue engineering. However, the development of an extracellular matrix in most tissues, including bone, is dependent upon the establishment of a well developed vascular supply. In this study a poly(d,l-lactic acid) (PDLLA) salt-leached sponge was modified by incorporation of silk fibroin fibers to create a multicomponent scaffold, in an effort to better support endothelial cell colonization and to promote in vivo vascularization. Scaffolds with and without silk fibroin fibers were compared for microstructure, mechanical properties, ability to maintain cell populations in vitro as well as to permit vascular ingrowth into acellular constructs in vivo. We demonstrated that adding silk fibroin fibers to a PDLLA salt-leached sponge enhanced scaffold properties and heightened its capacity to support endothelial cells in vitro and to promote vascularization in vivo. Therefore refinement of scaffold properties by inclusion of materials with beneficial attributes may promote and shape cellular responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.