ArticleMolecular plant pathology2013
A pepper (Capsicum annuum L.) metacaspase 9 (Camc9) plays a role in pathogen-induced cell death in plants.
Article in Molecular plant pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Genome-wide identification of the MCA gene family and its role in resistance to powdery mildew in wheat.BMC plant biology · 2026Article
- The role of plant metacaspases in cell death and survival.Cell death and differentiation · 2026Review
- RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy-mediated degradation of the viral silencing suppressor P6 protein.Plant biotechnology journal · 2025Article
- Phosphoenolpyruvate and Related Metabolic Pathways Contribute to the Regulation of Plant Growth and Development.International journal of molecular sciences · 2025Review
- Editing metacaspase (StMC7) gene enhances late blight resistance in Russet Burbank potato.PloS one · 2025Article
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- Review
- Regulating Death and Disease: Exploring the Roles of Metacaspases in Plants and Fungi.International journal of molecular sciences · 2022Review
- The potential roles of different metacaspases in maize defense response.Plant signaling & behavior · 2021Article
- Article
- Article
- Article
- Genome-wide characterization, molecular evolution and expression profiling of the metacaspases in potato (Heliyon · 2019Article
- Article
- Genome-wide identification of barley MCs (metacaspases) and their possible roles in boron-induced programmed cell death.Molecular biology reports · 2018Article
- TaMCA1, a regulator of cell death, is important for the interaction between wheat and Puccinia striiformis.Scientific reports · 2016Article
- Stress-Responsive Expression, Subcellular Localization and Protein-Protein Interactions of the Rice Metacaspase Family.International journal of molecular sciences · 2015Article
- Review
- New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants.Molecular & cellular proteomics : MCP · 2013Article
- The Arabidopsis thaliana METACASPASE IIf Regulates Sugar Metabolism and Delays Dark-Induced Leaf Senescence.Physiologia plantarumArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metacaspases, which belong to the cysteine-type C14 protease family, are most structurally similar to mammalian caspases than any other caspase-like protease in plants. Atmc9 (Arabidopsis thaliana metacaspase 9) has a unique domain structure, and distinct biochemical characteristics, such as Ca²⁺ binding, pH, redox status, S-nitrosylation and specific protease inhibitors. However, the biological roles of Atmc9 in plant-pathogen interactions remain largely unknown. In this study, a metacaspase gene present as a single copy in the pepper genome, and sharing 54% amino acid sequence identity with Atmc9, was isolated and named Capsicum annuum metacaspase 9 (Camc9). Camc9 encodes a 318-amino-acid polypeptide with an estimated molecular weight of 34.6 kDa, and shares approximately 40% amino acid sequence identity with known type II metacaspases in plants. Quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression of Camc9 was induced by infections of Xanthomonas campestris pv. vesicatoria race 1 and race 3 and treatment with methyl jasmonate. Suppression of Camc9 expression using virus-induced gene silencing enhanced disease resistance and suppressed cell death symptom development following infection with virulent bacterial pathogens. By contrast, overexpression of Camc9 by transient or stable transformation enhanced disease susceptibility and pathogen-induced cell death by regulation of reactive oxygen species production and defence-related gene expression. These results suggest that Camc9 is a possible member of the metacaspase gene family and plays a role as a positive regulator of pathogen-induced cell death in the plant kingdom.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.