ArticleCNS neuroscience & therapeutics2013
Eye-mediated induction of specific immune tolerance to encephalitogenic antigens.
Article in CNS neuroscience & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Pain perception enhancement in consecutive second-eye phacoemulsification cataract surgeries under topical anesthesia.International journal of ophthalmology · 2024Review
- Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life.Brain sciences · 2023Article
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- Retinal Degeneration: A Window to Understand the Origin and Progression of Parkinson's Disease?Frontiers in neuroscience · 2021Review
- Intravenous C16 and angiopoietin-1 improve the efficacy of placenta-derived mesenchymal stem cell therapy for EAE.Scientific reports · 2018Article
- Inhibition of experimental autoimmune encephalomyelitis by tolerance-promoting DNA vaccination focused to dendritic cells.PloS one · 2018Article
- Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space.The AAPS journal · 2017Review
- Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen.Scientific reports · 2017Article
- Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response.PloS one · 2017Article
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- The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models.PloS one · 2017Article
- Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity.PloS one · 2017Article
- Anterior chamber associated immune deviation used as a neuroprotective strategy in rats with spinal cord injury.PloS one · 2017Article
- Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin.Scientific reports · 2016Article
- Oral Tolerance Induction in Experimental Autoimmune Encephalomyelitis with Candida utilis Expressing the Immunogenic MOG35-55 Peptide.PloS one · 2016Article
- Adaptive Immunity in Schizophrenia: Functional Implications of T Cells in the Etiology, Course and Treatment.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Review
- Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination.PloS one · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAdministration of antigens into the anterior chamber (AC) of the eye induces a form of antigen-specific immune tolerance termed anterior chamber-associated immune deviation (ACAID). This immune tolerance effectively impairs host delayed-type hypersensitivity (DTH) responses. We hypothesized that ACAID could be generated in BALB/c mice following AC inoculation of the encephalitogenic antigens myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP).
methodsWe used DTH assays and local adoptive transfer (LAT) assays to test whether MOG/MBP-induced ACAID following their administration into the AC, whether they elicited this immune tolerance via CD8(+) T cells, and whether their AC coadministration (MOG/MBP) induced specific immune tolerance to one or both antigens.
resultsWe showed that MOG/MBP-induced AC-mediated specific immune tolerance, as evident from impaired DTH responses. This antigen-driven DTH suppression was solely mediated via splenic CD8(+) T cells as confirmed by LAT assays. Finally, a single AC injection with both antigens was sufficient to induce specific immune tolerance to these antigens, as evident from DTH and LAT assays.
conclusionACAID T-cell regulation could be used as a therapeutic tool in the treatment of complicated autoimmune diseases that involve multiple antigens such as multiple sclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.