ArticleWorld journal of surgical oncology2013
Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?
Article in World journal of surgical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Metastatic Lymph Node Ratio (mLNR) is a Useful Parameter in the Prognosis of Colorectal Cancer; A Meta-Analysis for the Prognostic Role of mLNR.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer.British journal of cancer · 2016Pooled it
- Prognostic and Predictive Value of Lymph Node Ratio in Stage III Colon Cancer in the Era of Molecular Biomarkers.Journal of the anus, rectum and colon · 2026Article
- Advancing Prognostic Accuracy Beyond Classical N Staging in Colorectal Cancer: An Observational Cohort Study to Define a Lymph Node Ratio Based Risk Score.Cancer management and research · 2025Article
- Prognostic value of metastatic lymph node ratio and its effect on disease-free survival in colon cancer.Frontiers in oncology · 2025Article
- Lymph node ratio is a more robust predictor of overall survival than N stage in stage III colorectal adenocarcinoma.Diagnostic pathology · 2024Review
- Article
- SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis.Cancer biology & therapy · 2023Article
- Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location.Journal of clinical medicine · 2019Article
- Lymph Node Ratio Versus TNM System As Prognostic Factor in Colorectal Cancer Staging. a Single Center Experience.Open medicine (Warsaw, Poland) · 2019Article
- Lymph node ratio is inferior to pN-stage in predicting outcome in colon cancer patients with high numbers of analyzed lymph nodes.BMC surgery · 2018Article
- Assessment of lymph node involvement in colorectal cancer.World journal of gastrointestinal surgery · 2016Review
- Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection.British journal of cancer · 2015Article
- Lymph node ratio improves TNM and Astler-Coller's assessment of colorectal cancer prognosis: an analysis of 761 node positive cases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
- Zinc finger protein 185 is a liver metastasis-associated factor in colon cancer patients.Molecular and clinical oncology · 2014Article
- Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients.British journal of cancer · 2014Article
- Lymph node staging in colorectal cancer: old controversies and recent advances.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDecision making for adjuvant chemotherapy in stage III colon cancer is based on the TNM system. It is well known that prognosis worsens with higher pN classification, and several recent studies propose superiority of the lymph node ratio (ln ratio) to the TNM system. Therefore, we compared the prognosis of ln ratio to TNM system in our stage III colon cancer patients.
methodsA total of 939 patients underwent radical surgery for colorectal cancer between January 2000 and December 2009. From this pool of patients, 142 colon cancer stage III patients were identified and taken for this analysis. Using martingale residuals, this cohort could be separated into a group with a low ln ratio and one with a high ln ratio. These groups were compared to pN1 and pN2 of the TNM system.
resultsFor ln ratio, the cutoff was calculated at 0.2. There was a good prognosis of disease-free and cancer-related survival for the N-category of the TNM system as well as for the lymph node ratio. There was no statistical difference between using the N-category of the TNM system and the ln ratio.
conclusionsThere might not be a benefit in using the lymph node ratio rather than the N category of the TNM system as long as the number of subgroups is not increased. In our consideration, there is no need to change the N categorization of the TNM system to the ln ratio.
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