ArticleBMC medical genetics2013
Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy.
Article in BMC medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Role of Epigenetics in Chronic Lung Disease.Cells · 2025Review
- USNAP: fast unique dense region detection and its application to lung cancer.Bioinformatics (Oxford, England) · 2023Article
- DNA methylation biomarkers in asthma and rhinitis: Are we there yet?Clinical and translational allergy · 2022Review
- The Airway Epithelium-A Central Player in Asthma Pathogenesis.International journal of molecular sciences · 2020Review
- Epigenetic Regulation of Airway Epithelium Immune Functions in Asthma.Frontiers in immunology · 2020Review
- Epigenetic Changes in Asthma: Role of DNA CpG Methylation.Tuberculosis and respiratory diseases · 2020Review
- Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease.Allergy, asthma & immunology research · 2019Review
- Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.The Journal of allergy and clinical immunology · 2019Article
- Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization.Epigenetics · 2019Article
- Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming.Frontiers in genetics · 2019Article
- Using omics approaches to understand pulmonary diseases.Respiratory research · 2017Review
- Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle.The Journal of allergy and clinical immunology · 2017Article
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- Review
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- Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects.Yonsei medical journal · 2015Review
- Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases.Current allergy and asthma reports · 2015Review
- Genome-wide analysis of DNA methylation before-and after exercise in the thoroughbred horse with MeDIP-Seq.Molecules and cells · 2015Article
- Systems biology of asthma and allergic diseases: a multiscale approach.The Journal of allergy and clinical immunology · 2015Review
- Epigenetics and development of food allergy (FA) in early childhood.Current allergy and asthma reports · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a common respiratory disease that is characterized by bronchial hyperresponsiveness and airway obstruction due to chronic airway inflammation. Atopic asthma is a typical IgE-mediated disease in which the enhanced production of IgE is driven by the activation of Th2 cells, which release a distinct pattern of cytokines, including interleukin 4 (IL4) and IL3, in response to specific antigen presentation. To evaluate the methylation status of the whole genomes of bronchial mucosa tissues from subjects who lacked or had sensitization to Dermatophagoides farina (Df) and Dermatophagoides pteronyssinus (Dp).
methodsThe genome-wide DNA methylation levels in the bronchial mucosa tissues of atopic asthmatics (N=10), non-atopic asthmatics (N=7), and normal controls (N=7) were examined using microarrays.
resultsIn the bronchial mucosa of atopic asthmatics, hypermethylation was detected at 6 loci in 6 genes, while hypomethylation was detected at 49 loci in 48 genes compared to those of non-atopic asthmatics. Genes that were assigned the ontologies of multicellular organismal process, response to organic substance, hormone metabolic process, and growth factor receptor binding were hypomethylated. The methylation levels in the mucosa of asthmatics and normal controls were similar.
conclusionsThe bronchial mucosa of asthmatics who are atopic to Df or Dp have characteristic methylation patterns for 52 genes. The genes and pathways identified in the present study may be associated with the presence of atopy in asthmatics and therefore represent attractive targets for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.