ArticleChemistry & biology2013
Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides.
Article in Chemistry & biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Backbone Steric Constraints Underlie High Passive Membrane Permeability of N-Alkyl Peptides.Angewandte Chemie (International ed. in English) · 2026Article
- Proximity-driven acceleration of challenging solid-phase peptide couplings.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications.Chemical reviews · 2025Review
- Solid-Phase Synthesis of Peptides with Methyl and Larger Substituents on Backbone Amide Nitrogens via On-Resin Incorporation of the Substituents.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2.Chemical science · 2024Article
- Beyond N-Alkylation: Synthesis, Structure, and Function of N-Amino Peptides.Accounts of chemical research · 2024Article
- Synthesis, derivatization, and conformational scanning of peptides containing N-Aminoglycine.Methods in enzymology · 2024Article
- Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins.ACS omega · 2022Article
- First series ofBeilstein journal of organic chemistry · 2022Article
- Peptoid-based reprogrammable template for cell-permeable inhibitors of protein-protein interactions.Chemical science · 2021Article
- High-Throughput Quality Control Assay for the Solid-Phase Synthesis of DNA-Encoded Libraries of Macrocycles*.Angewandte Chemie (International ed. in English) · 2021Article
- Piptides: New, Easily Accessible Chemotypes For Interactions With Biomolecules.Angewandte Chemie (International ed. in English) · 2021Article
- Structural characterization of a peptoid-inspired conformationally constrained oligomer (PICCO) bound to streptavidin.Chemical communications (Cambridge, England) · 2020Article
- Solid-Phase Insertion ofMolecules (Basel, Switzerland) · 2019Article
- Chemical composition of DNA-encoded libraries, past present and future.Organic & biomolecular chemistry · 2019Review
- Tuning of protease resistance in oligopeptides through N-alkylation.Chemical communications (Cambridge, England) · 2018Article
- Tuning conformation and properties of peptidomimetic backbones through dual N/CChemical communications (Cambridge, England) · 2018Article
- Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions.ACS combinatorial science · 2018Article
- Asymmetric synthesis of vinylogous β-amino acids and their incorporation into mixed backbone oligomers.Organic & biomolecular chemistry · 2017Article
- Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.ACS combinatorial science · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Large combinatorial libraries of N-substituted peptides would be an attractive source of protein ligands, because these compounds are known to be conformationally constrained, whereas standard peptides or peptoids are conformationally mobile. Here, we report an efficient submonomer solid-phase synthetic route to these compounds and demonstrate that it can be used to create high quality libraries. A model screening experiment and analysis of the hits indicates that the rigidity afforded by the stereocenters is critical for high affinity binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.