ReviewILAR journal2012
Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.
Review in ILAR journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Ketogenic Diet Decreases Alcohol Intake in Adult Male Mice.Nutrients · 2021Article
- Neuropeptidergic Control of Feeding: Focus on the Galanin Family of Peptides.International journal of molecular sciences · 2021Review
- The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet.Cellular and molecular life sciences : CMLS · 2021Article
- Access schedules mediate the impact of high fat diet on ethanol intake and insulin and glucose function in mice.Alcohol (Fayetteville, N.Y.) · 2020Article
- Effects of ethanol on plasma ghrelin levels in the rat during early and late adolescence.Alcohol (Fayetteville, N.Y.) · 2020Article
- Expression of neural markers of gustatory signaling are differentially altered by continuous and intermittent feeding patterns.Physiology & behavior · 2019Article
- Incubation of feeding behavior is regulated by neuromedin U receptor 2 in the paraventricular nucleus of the hypothalamus.Behavioural brain research · 2019Article
- Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking.Addiction biology · 2019Article
- The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors.Frontiers in systems neuroscience · 2017Review
- Regulation of motivation for food by neuromedin U in the paraventricular nucleus and the dorsal raphe nucleus.International journal of obesity (2005) · 2017Article
- Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons.Peptides · 2016Article
- Effects of embryonic ethanol exposure at low doses on neuronal development, voluntary ethanol consumption and related behaviors in larval and adult zebrafish: Role of hypothalamic orexigenic peptides.Behavioural brain research · 2016Article
- Article
- Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.Alcohol (Fayetteville, N.Y.) · 2015Article
- Model of voluntary ethanol intake in zebrafish: effect on behavior and hypothalamic orexigenic peptides.Behavioural brain research · 2015Article
- Hypothalamic QRFP: regulation of food intake and fat selection.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Consummatory behavior is driven by both caloric and emotional need, and a wide variety of animal models have been useful in research on the systems that drive consumption of food and drugs. Models have included selective breeding for a specific trait, manipulation of gene expression, forced or voluntary exposure to a substance, and identification of biomarkers that predict which animals are prone to overconsuming specific substances. This research has elucidated numerous brain areas and neurochemicals that drive consummatory behavior. Although energy homeostasis is primarily mediated by the hypothalamus, reinforcement is more strongly mediated by nuclei outside the hypothalamus, in mesocorticolimbic regions. Orexigenic neurochemicals that control food intake can provide a general signal for promoting caloric intake or a more specific signal for stimulating consumption of a particular macronutrient, fat, carbohydrate, or protein. The neurochemicals involved in controlling fat ingestion--galanin, enkephalin, orexin, melanin-concentrating hormone, and the endocannabinoids--show positive feedback with this macronutrient, as these peptides both increase fat intake and are further stimulated by its intake. This positive association offers some explanation for why foods high in fat are so often overconsumed. Consumption of ethanol, a drug of abuse that also contains calories, is similarly driven by the neurochemical systems involved in fat intake, according to evidence that closely relates fat and ethanol consumption. Further understanding of the systems involved in consummatory behavior will enable the development of effective therapies for the treatment of both overeating and drug abuse.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.