ArticlePloS one2013
RETRACTED: AQP4-dependent water transport plays a functional role in exercise-induced skeletal muscle adaptations.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Repeated heat exposure upregulates skeletal muscle aquaporin-4 expression in male mice.Physiological reports · 2026Article
- Retraction: AQP4-Dependent Water Transport Plays a Functional Role in Exercise-Induced Skeletal Muscle Adaptations.PloS one · 2026Article
- Aquaporin-4 downregulation in dysphagic patients with idiopathic inflammatory myopathies: myofiber vulnerability and inflammation drivers.Rheumatology (Oxford, England) · 2025Article
- Molecular determinants of skeletal muscle force loss in response to 5 days of dry immersion in human.Journal of cachexia, sarcopenia and muscle · 2024Article
- Aquaporin 4 Expression Level Is Decreased in Skeletal Muscles with Aging.The Kobe journal of medical sciences · 2023Article
- Assessing the Role of Aquaporin 4 in Skeletal Muscle Function.International journal of molecular sciences · 2023Review
- AQP4-independent TRPV4 modulation of plasma membrane water permeability.Frontiers in cellular neuroscience · 2023Article
- Decrease in AQP4 expression level in atrophied skeletal muscles with innervation.Physiological reports · 2021Article
- Atrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy.Scientific reports · 2020Article
- Review
- Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions.European journal of applied physiology · 2020Article
- Review
- A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica.Nature communications · 2018Article
- The expression of aquaporin-4 is regulated based on innervation in skeletal muscles.Journal of muscle research and cell motility · 2018Article
- Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.Journal of cellular and molecular medicine · 2018Article
- Exploring the genetics of feed efficiency and feeding behaviour traits in a pig line highly selected for performance characteristics.Molecular genetics and genomics : MGG · 2017Article
- High fructose diet suppresses exercise-induced increase in AQP7 expression in the in vivo rat heart.Anatolian journal of cardiology · 2016Article
- A Nanoscale Interface Promoting Molecular and Functional Differentiation of Neural Cells.Scientific reports · 2016Article
- Methamphetamine alters microglial immune function through P2X7R signaling.Journal of neuroinflammation · 2016Article
- Molecular pathophysiology of cerebral edema.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
Corrections and comments
- Correction · 2013-06-18Error in Image · Error in Text · Updated to Retraction · · See also: https://pubpeer.com/publications/806570430175F751742D242CF4E007
- Retraction · 2026-03-26Concerns/Issues about Image · Concerns/Issues about Results and/or Conclusions · Duplication of/in Image · Euphemisms for Duplication · Original Data and/or Images not Provided and/or not Available · Upgrade/Update of Prior Notice(s) · · See also: https://pubpeer.com/publications/806570430175F751742D242CF4E007
- Erratum issued
- Retracted
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we assess the functional role of Aquaporin-4 (AQP4) in the skeletal muscle by analyzing whether physical activity modulates AQP4 expression and whether the absence of AQP4 has an effect on osmotic behavior, muscle contractile properties, and physical activity. To this purpose, rats and mice were trained on the treadmill for 10 (D10) and 30 (D30) days and tested with exercise to exhaustion, and muscles were used for immunoblotting, RT-PCR, and fiber-type distribution analysis. Taking advantage of the AQP4 KO murine model, functional analysis of AQP4 was performed on dissected muscle fibers and sarcolemma vesicles. Moreover, WT and AQP4 KO mice were subjected to both voluntary and forced activity. Rat fast-twitch muscles showed a twofold increase in AQP4 protein in D10 and D30 rats compared to sedentary rats. Such increase positively correlated with the animal performance, since highest level of AQP4 protein was found in high runner rats. Interestingly, no shift in muscle fiber composition nor an increase in AQP4-positive fibers was found. Furthermore, no changes in AQP4 mRNA after exercise were detected, suggesting that post-translational events are likely to be responsible for AQP4 modulation. Experiments performed on AQP4 KO mice revealed a strong impairment in osmotic responses as well as in forced and voluntary activities compared to WT mice, even though force development amplitude and contractile properties were unvaried. Our findings definitively demonstrate the physiological role of AQP4 in supporting muscle contractile activity and metabolic changes that occur in fast-twitch skeletal muscle during prolonged exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.