Trial reportPloS one2013
The dental plaque microbiome in health and disease.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03693027 (Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults), which is not on this map. Cited by 115 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults
Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of pomegranate extract on preventing dental caries: a systematic review.Frontiers in oral health · 2025Pooled it
- An oral health optimized diet reduces the load of potential cariogenic and periodontal bacterial species in the supragingival oral plaque: A randomized controlled pilot study.MicrobiologyOpen · 2020Trial
- A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology.Scientific reports · 2017Trial
- Association between red biofluorescence and microbial dysbiosis in cariogenic biofilms: an in vitro study.Scientific reports · 2026Article
- Paired oral clinical specimens reveal the underlying ecology supporting the emergence of inflammophilic microbiome communities.bioRxiv : the preprint server for biology · 2026Article
- Evaluating the Impact of Clear Dental Aligners on Dental and Periodontal Conditions, Oral Microbial Patterns, and the Immune System.Advances in experimental medicine and biology · 2026Review
- Caries Index and Salivary Factors in Children: A Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Mechanism of Action of Zinc Oxide Nanoparticles as an Antibacterial Agent AgainstBiomolecules · 2025Article
- Probiotics to reduce microbiota-related dental stains: A potential approach.Journal of dental sciences · 2025Article
- Ex vivo oral biofilm model for rapid screening of antimicrobial agents including natural cranberry polyphenols.Scientific reports · 2025Article
- Metagenomic profiling of plaque microbiota in Indian subjects: identified hidden ecological tapestry.Current genetics · 2025Article
- Microbiome variability and role ofJournal of oral microbiology · 2025Article
- Article
- Evaluation and comparison of microbial colonization on nickel titanium (NiTi) closed coil springs and active tie-backs during orthodontic space closure: AnJournal of orthodontic science · 2025Article
- Effects of removable clear dental aligners on the composition of the oral microbiome.Journal of oral microbiology · 2025Article
- Dynamic effects of fixed orthodontic treatment on oral health and oral microbiota: a prospective study.BMC oral health · 2024Article
- Streptococci Biotypes in Primary and Permanent Caries: A Case-Control Study.International journal of clinical pediatric dentistry · 2024Article
- Ethnicity-based analysis of supragingival plaque composition and dental health behaviours in healthy subjects without caries.Heliyon · 2024Article
- Article
- Maternal and infant oral health benefits from mothers receiving prenatal total oral rehabilitation: a pilot prospective birth cohort study.Frontiers in oral health · 2024Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental health and disease. The purpose of the current study was to improve our knowledge of the microbial species involved in dental caries and health by performing a comprehensive 16S rDNA profiling of the dental plaque microbiome of both caries-free and caries-active subjects. Analysis of over 50,000 nearly full-length 16S rDNA clones allowed the identification of 1,372 operational taxonomic units (OTUs) in the dental plaque microbiome. Approximately half of the OTUs were common to both caries-free and caries-active microbiomes and present at similar abundance. The majority of differences in OTU's reflected very low abundance phylotypes. This survey allowed us to define the population structure of the dental plaque microbiome and to identify the microbial signatures associated with dental health and disease. The deep profiling of dental plaque allowed the identification of 87 phylotypes that are over-represented in either caries-free or caries-active subjects. Among these signatures, those associated with dental health outnumbered those associated with dental caries by nearly two-fold. A comparison of this data to other published studies indicate significant heterogeneity in study outcomes and suggest that novel approaches may be required to further define the signatures of dental caries onset and progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.