ArticlePloS one2013
Soybean β-conglycinin induces inflammation and oxidation and causes dysfunction of intestinal digestion and absorption in fish.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 163 citations in OpenAlex.
- Lysine and methionine supplementation ameliorates high inclusion of soybean meal inducing intestinal oxidative injury and digestive and antioxidant capacity decrease of yellow catfish.Fish physiology and biochemistry · 2018Trial
- Effects of phytase and protease supplementation, with and without considering their nutritional matrix values, on the productive performance of laying hens during the late‑lay period.Veterinary and animal science · 2026Article
- Effects of protease and lipase supplementation in starter diet on growth performance, small intestine morphology, and immunity in young broilers.Veterinary and animal science · 2026Article
- Sodium butyrate improved intestinal function in normal and glyphosate-challenged Nile tilapia (Oreochromis niloticus L.).Fish physiology and biochemistry · 2026Article
- Tributyrin enhances growth and intestinal health in green mud crab (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Roles ofJournal of Zhejiang University. Science. B · 2025Article
- Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1α signal pathway and modulation of gut microbiota.Scientific reports · 2025Article
- Neuropeptide Y receptor Y8b (Journal of Zhejiang University. Science. B · 2024Article
- Mechanism of action, benefits, and research gap in fermented soybean meal utilization as a high-quality protein source for livestock and poultry.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals.Antioxidants (Basel, Switzerland) · 2023Review
- An integrated study of glutamine alleviates enteritis induced by glycinin in hybrid groupers using transcriptomics, proteomics and microRNA analyses.Frontiers in immunology · 2023Article
- Positive effects of dietaryFrontiers in immunology · 2023Article
- Potential of algae-derived alginate oligosaccharides and β-glucan to counter inflammation in adult zebrafish intestine.Frontiers in immunology · 2023Article
- Effects of tributyrin and alanyl-glutamine dipeptide on intestinal health of largemouth bass (Frontiers in immunology · 2023Article
- Fishmeal, plant protein, and fish oil substitution with single-cell ingredients in organic feeds for European sea bass (Frontiers in physiology · 2023Article
- Partial Substitution of Fish Meal with Soy Protein Concentrate on Growth, Liver Health, Intestinal Morphology, and Microbiota in Juvenile Large Yellow Croaker (Aquaculture nutrition · 2023Article
- Dietary α-ketoglutarate alleviates glycinin and β-conglycinin induced damage in the intestine of mirror carp (Frontiers in immunology · 2023Article
- Anti-Nutritional Factors and Protein Dispersibility Index as Principal Quality Indicators for Soybean Meal in Diet of Nile Tilapia (Animals : an open access journal from MDPI · 2022Article
- Soybean β-conglycinin and glycinin reduced growth performance and the intestinal immune defense and altered microbiome in juvenile pearl gentian groupersAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Dietary sodium butyrate supplementation attenuates intestinal inflammatory response and improves gut microbiota composition in largemouth bass (Micropterus salmoides) fed with a high soybean meal diet.Fish physiology and biochemistry · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-Conglycinin has been identified as one of the major feed allergens. However, studies of β-conglycinin on fish are scarce. This study investigated the effects of β-conglycinin on the growth, digestive and absorptive ability, inflammatory response, oxidative status and gene expression of juvenile Jian carp (Cyprinus carpio var. Jian) in vivo and their enterocytes in vitro. The results indicated that the specific growth rate (SGR), feed intake, and feed efficiency were reduced by β-conglycinin. In addition, activities of trypsin, chymotrypsin, lipase, creatine kinase, Na(+),K(+)-ATPase and alkaline phosphatase in the intestine showed similar tendencies. The protein content of the hepatopancreas and intestines, and the weight and length of the intestines were all reduced by β-conglycinin. β-Conglycinin increased lipid and protein oxidation in the detected tissues and cells. However, β-conglycinin decreased superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GR) activities and glutathione (GSH) content in the intestine and enterocytes. Similar antioxidant activity in the hepatopancreas was observed, except for GST. The expression of target of rapamycin (TOR) gene was reduced by β-conglycinin. Furthermore, mRNA levels of interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) genes were increased by β-conglycinin. However, β-conglycinin increased CuZnSOD, MnSOD, CAT, and GPx1b gene expression. In conclusion, this study indicates that β-conglycinin induces inflammation and oxidation, and causes dysfunction of intestinal digestion and absorption in fish, and finally reduces fish growth. The results of this study provide some information to the mechanism of β-conglycinin-induced negative effects.
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