Trial reportPloS one2013
Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Epidemiological trends and risk factors associated with dengue disease in Pakistan (1980-2014): a systematic literature search and analysis.BMC public health · 2018Pooled it
- Dengue in the Middle East and North Africa: A Systematic Review.PLoS neglected tropical diseases · 2016Pooled it
- Genetic regions affecting the replication and pathogenicity of dengue virus type 2.PLoS neglected tropical diseases · 2024Article
- Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017.The American journal of tropical medicine and hygiene · 2023Article
- Genetic Analysis of Dengue Virus in Severe and Non-Severe Cases in Dhaka, Bangladesh, in 2018-2022.Viruses · 2023Article
- Article
- Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2.Scientific reports · 2021Article
- Prevalence of dengue virus serotypes in the 2017 outbreak in Peshawar, KP, Pakistan.Journal of clinical laboratory analysis · 2020Article
- Quantifying the localized relationship between vector containment activities and dengue incidence in a real-world setting: A spatial and time series modelling analysis based on geo-located data from Pakistan.PLoS neglected tropical diseases · 2020Article
- Isolation and molecular characterization of dengue virus clinical isolates from pediatric patients in New Delhi.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Spatiotemporal analysis of dengue outbreaks in Samanabad town, Lahore metropolitan area, using geospatial techniques.Environmental monitoring and assessment · 2019Article
- Emergence of genotype Cosmopolitan of dengue virus type 2 and genotype III of dengue virus type 3 in Thailand.PloS one · 2018Article
- Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening.Frontiers in chemistry · 2017Article
- Molecular epidemiology and evolutionary analysis of dengue virus type 2, circulating in Delhi, India.Virusdisease · 2016Article
- Fine-grained dengue forecasting using telephone triage services.Science advances · 2016Article
- Complete genome sequencing and comparative analysis of three dengue virus type 2 Pakistani isolates.Virusdisease · 2016Article
- DGV: Dengue Genographic Viewer.Frontiers in microbiology · 2016Article
- A Comprehensive Entomological, Serological and Molecular Study of 2013 Dengue Outbreak of Swat, Khyber Pakhtunkhwa, Pakistan.PloS one · 2016Article
- Big city, small world: density, contact rates, and transmission of dengue across Pakistan.Journal of the Royal Society, Interface · 2015Article
- Introduction and evolution of dengue virus type 2 in Pakistan: a phylogeographic analysis.Virology journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and resulted in 21,685 confirmed cases and 350 deaths. To investigate the possible viral causes for the increased epidemic activity, we determined the predominant serotype and characterized the viruses genetically. Of 50 patients carefully selected as probable dengue fever or dengue hemorrhagic fever, 34 were positive by virologic testing (i.e. PCR and/or virus isolation). DENV-2 was detected in 32 patients and DENV-1 in two. A total of 24 partial and three full DENV genomes were sequenced. Phylogenetic analyses of the capsid (C), pre-membrane (prM), and envelope genes comprising 2500 nucleotides in length indicated that all DENV-2 isolates in Pakistan since 2007 form a monophyletic lineage that is endemic in the country. These viruses were all of the cosmopolitan genotype (IV) and most closely related to viruses isolated in India and Sri Lanka in the past two decades. Phylogenetic analyses of data currently available in GenBank suggest that the Cosmopolitan genotype has diverged into two geographically distinct sub-lineages: sub-lineage IV-a has only been observed in Southeast Asia, China and Oceania, while IV-b is prevalent in the Indian subcontinent. These results highlight the increased diversity of dengue viruses as they spread geographically within the region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.