ArticleCurrent organic synthesis2011
Activatable Optical Probes for the Detection of Enzymes.
Article in Current organic synthesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Synthesis, Photophysical Properties, and Practical Hg(II)-Sensing Applications of a Rigidified Phenolo-Merocyanine Dye.Chemistry, an Asian journal · 2025Article
- Turn-on Fluorescent Biosensors for Imaging Hypoxia-like Conditions in Living Cells.Journal of the American Chemical Society · 2022Article
- Enzyme assays with supramolecular chemosensors - the label-free approach.RSC advances · 2022Review
- Emerging Approaches for Fluorescence-Based Newborn Screening of Mucopolysaccharidoses.Diagnostics (Basel, Switzerland) · 2020Review
- Sulfatase-cleavable linkers for antibody-drug conjugates.Chemical science · 2020Article
- Interaction of Cucurbit[7]uril With Protease Substrates: Application to Nanosecond Time-Resolved Fluorescence Assays.Frontiers in chemistry · 2020Article
- Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.Organic & biomolecular chemistry · 2015Article
- An ultra-sensitive dual-mode imaging system using metal-enhanced fluorescence in solid phantoms.Nano research · 2015Article
- MMP-2/9-Specific Activatable Lifetime Imaging Agent.Sensors (Basel, Switzerland) · 2015Article
- Detecting enzyme activities with exogenous MRI contrast agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Review
- Bright building blocks for chemical biology.ACS chemical biology · 2014Review
- Photoacoustic lifetime contrast between methylene blue monomers and self-quenched dimers as a model for dual-labeled activatable probes.Journal of biomedical optics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The early detection of many human diseases is crucial if they are to be treated successfully. Therefore, the development of imaging techniques that can facilitate early detection of disease is of high importance. Changes in the levels of enzyme expression are known to occur in many diseases, making their accurate detection at low concentrations an area of considerable active research. Activatable fluorescent probes show immense promise in this area. If properly designed they should exhibit no signal until they interact with their target enzyme, reducing the level of background fluorescence and potentially endowing them with greater sensitivity. The mechanisms of fluorescence changes in activatable probes vary. This review aims to survey the field of activatable probes, focusing on their mechanisms of action as well as illustrating some of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.