ArticleNucleic acids research2013
Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Epigenetic switching with asymmetric bridging interactions.Biophysical journal · 2023Article
- Complex small-world regulatory networks emerge from the 3D organisation of the human genome.Nature communications · 2021Article
- Establishment of heterochromatin in domain-size-dependent bursts.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Boosting functionality of synthetic DNA circuits with tailored deactivation.Nature communications · 2016Article
- Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nucleation and spreading of a heterochromatic domain in fission yeast.Nature communications · 2016Article
- Nanog, Oct4 and Tet1 interplay in establishing pluripotency.Scientific reports · 2016Article
- Monoallelic expression of olfactory receptors.Annual review of cell and developmental biology · 2015Review
- Rare event of histone demethylation can initiate singular gene expression of olfactory receptors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory system integrates signals from receptors expressed in olfactory sensory neurons. Each sensory neuron expresses only one of many similar olfactory receptors (ORs). The choice of receptor is made stochastically early in the differentiation process and is maintained throughout the life of the neuron. The underlying mechanism of this stochastic commitment to one of multiple similar OR genes remains elusive. We present a theoretical analysis of a mechanism that invokes important epigenetic properties of the system. The proposed model combines nucleosomes and associated read-write enzymes as mediators of a cis-acting positive feedback with a trans-acting negative feedback, thereby coupling the local epigenetic landscape of the individual OR genes in a way that allow one and only one gene to be active at any time. The model pinpoint that singular gene selection does not require transient mechanisms, enhancer elements or transcription factors to separate choice from maintenance. In addition, our hypothesis allow us to combine all reported characteristics of singular OR gene selection, in particular that OR genes are silenced from OR transgenes. Intriguingly, it predicts that OR transgenes placed in close proximity should always be expressed simultaneously, though rarely.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.