ArticlePediatric nephrology (Berlin, Germany)2013
Epidemiology of cardiac surgery-associated acute kidney injury in neonates: a retrospective study.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02960867 (European Registry of Dialysis Treatment of Pediatric Acute Kidney Injury), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
European Registry of Dialysis Treatment of Pediatric Acute Kidney Injury (AKI)
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Machine learning model predicts acute kidney injury in pediatric patients after cardiac surgery: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Risk factors and mortality of postoperative acute kidney injury (AKI) in newborns across geographical regions, surgical type, and national economic levels: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Exploring Racial and Ethnic Disparities in Outcomes Following Pediatric Cardiac Surgery: A NEPHRON Study Analysis.Pediatric cardiology · 2026Article
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Using health systems evidence to study and predict long-term outcomes of childhood acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2026Article
- Urine Output Response to a Furosemide Infusion in Infants After Cardiopulmonary Bypass as a Predictor of Acute Kidney Injury.Pediatric cardiology · 2026Article
- Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Urine dipstick blood and acute kidney injury in infants undergoing cardiopulmonary bypass.Pediatric nephrology (Berlin, Germany) · 2024Article
- Minimizing Acute Kidney Injury in Pediatric Cardiac Surgery: Incidence, Early Detection, and Preemptive Measures.Cureus · 2024Article
- Acute kidney injury requiring dialysis in children: a multicentric, emerging country perspective.Pediatric nephrology (Berlin, Germany) · 2024Article
- Acute kidney injury after arterial switch operation: incidence, risk factors, clinical impact - a retrospective single-center study.Renal failure · 2023Article
- Kidney outcomes in early adolescence following perinatal asphyxia and hypothermia-treated hypoxic-ischaemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Acute Kidney Injury Predictors and Outcomes after Cardiac Surgery in Children with Congenital Heart Disease: An Observational Cohort Study.Diagnostics (Basel, Switzerland) · 2022Article
- Neonatal Acute Kidney Injury.Frontiers in pediatrics · 2022Review
- Association of Preoperative Diuretic Use With Early Acute Kidney Injury in Infants With Biventricular Hearts Following Cardiac Surgery.Journal of the American Heart Association · 2021Article
- Higher total ultrafiltration volume during cardiopulmonary bypass-assisted infant cardiac surgery is associated with acute kidney injury and fluid overload.Pediatric nephrology (Berlin, Germany) · 2021Article
- Extracardiac Complications in Intensive Care Units after Surgical Repair for Congenital Heart Disease: Imaging Review with a Focus on Ultrasound and Radiography.Journal of pediatric intensive care · 2021Review
- Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates.Pediatric nephrology (Berlin, Germany) · 2021Article
- Follow-up after neonatal heart disease repair: watch out for chronic kidney disease and hypertension!Pediatric nephrology (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac surgery is a known risk factor for acute kidney injury (AKI) in children. However, cardiac surgery-associated AKI (CS-AKI) in neonates has not been well studied. The objectives of this study were: (1) to describe the epidemiology of CS-AKI in neonates utilizing the Acute Kidney Injury Network (AKIN) definition, (2) to identify risk factors for neonatal CS-AKI, and (3) to determine if neonatal CS-AKI is associated with increased morbidity and mortality.
methodsThis was a retrospective study involving 122 neonates (≤28 days) undergoing cardiac surgery from 2006 to 2009. Neonates with and without AKI were identified using serum creatinine (SCr) and urine output (UO) data.
resultsCardiac surgery-AKI occurred in 76 (62 %) neonates, of whom 22 (29 %) were AKIN stage 1, 19 (25 %) were stage 2, and 35 (46 %) were stage 3. AKI mostly occurred early as 75 % of patients achieved their maximal AKIN stage within the first 48 h post-operatively. In the multivariate analysis, cardiopulmonary bypass duration of ≥120 min was independently associated with AKI [odds ratio (OR) 2.53, 95 % confidence interval (CI) 1.03-6.30]. Severe AKI (AKIN stage 3) was independently associated with mortality (OR 6.70, 95 % CI 1.08-41.50) and a longer stay in the pediatric intensive care unit (hazard ratio 9.09, 95 % CI 1.35-60.95). The majority of severe AKI cases (65 %) were identified with AKIN UO criteria alone without significant rises in SCr.
conclusionsCardiac surgery-AKI is common in neonates when the AKIN definition is utilized and is associated with higher morbidity and mortality, especially in those with more severe AKI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.