Evidence map›Paper›PMID 23519500›Full record

ReviewSwiss medical weekly2013

Illuminating human health through cell mechanics.

Robert L Steward, Sonia R Rosner, Enhua H Zhou, Jeffrey J Fredberg

Abstract readReview
In one paragraph

Review in Swiss medical weekly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert L StewardProgram in Molecular and Integrative Physiological Sciences School of Public Health, Harvard University, Boston, Massachusetts, USA. rsteward@hsph.harvard.edu
Sonia R Rosner
Enhua H Zhou
Jeffrey J Fredberg

Funding

Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Micromechanics of the airway smooth muscle cellR01HL065960 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FREDBERG, JEFFREY J · 2000 to 2009
$6.3M
Mechanics of Monolayer MigrationR01HL107561 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2011 to 2015
$3.1M
AIRWAY MECHANICS AND SMOOTH MUSCLE SHORTENINGR01HL059682 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FREDBERG, JEFFREY J · 1998 to 2006
$2.7M
The resident cell in the asthmatic airway: A victim of its physical microenvironR01HL102373 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, TSCHUMPERLIN, DANIEL J. · 2011 to 2014
$1.9M
Remodeling of the airway smooth muscle cellR01HL084224 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2006 to 2009
$1.6M
NHLBI NIH HHS R01 HL059682NHLBI NIH HHS R01 HL065960NHLBI NIH HHS R01 HL084224NHLBI NIH HHS R01 HL102373NHLBI NIH HHS R01 HL107561NHLBI NIH HHS T32 HL007118
6 · The paper itself

Abstract

Cells reside in mechanically rich and dynamic microenvironments, and the complex interplay between mechanics and biology is widely acknowledged. Recent research has yielded insights linking the mechanobiology of cells, human physiology, and pathophysiology. In particular, we have learned of the cell's astounding ability to sense and respond to its mechanical microenvironment. This seemingly innate behaviour of the cell has driven efforts to characterise precisely the cellular behaviour from a mechanical viewpoint. Here we present an overview of technologies used to probe cell mechanical and material properties, how they have led to the discovery of seemingly strange cellular mechanical behaviours, and their influential role in health and disease, including asthma, cancer, and glaucoma. The properties reviewed here have implications in physiology and pathology and raise questions that will fuel research opportunities for years to come.

Indexed as

Cell BiologyAsthmaBiomechanical PhenomenaBronchial HyperreactivityCell MovementCytological TechniquesGlaucomaHumansMicroscopyNeoplasms

Identifiers

PMID23519500
PMCPMC3888799

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.