ArticleFrontiers in endocrinology2013
Testicular cancer and cryptorchidism.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Testicular microlithiasis and testicular cancer: review of the literature.International urology and nephrology · 2016Pooled it
- The great pretender: Torsion of a giant intra-abdominal seminoma presenting as acute appendicitis-A rare diagnostic trap.Urology case reports · 2026Article
- Testicular seminoma: clinical, imaging, and histologic features in nine horses.Journal of veterinary internal medicine · 2026Article
- Undescended Testis in a Zambian Cadaver: A Cadaveric Case Report With Anatomical and Clinical Correlation.Cureus · 2026Article
- Article
- Multi-omics highlights the impacts of cryptorchidism history on immune microenvironment variation in TGCT.Discover oncology · 2025Article
- Testicular cancer in Latvia: incidence trends and prognostic outcomes across a 23-year study.BMC cancer · 2025Article
- Review
- MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer.Molecular oncology · 2025Article
- Germ cell tumors in children.Virchows Archiv : an international journal of pathology · 2025Review
- Identification of Ferroptosis-Related Genes Associated With Cryptorchidism via Bioinformatics and Experimental Verification.Genetics research · 2025Article
- Delayed Presentation of Mixed Testicular Tumor 19 Years After Orchiopexy: A Case Report and Literature Review.Research and reports in urology · 2025Article
- Article
- Hereditary and Familial Traits in Urological Cancers and Their Underlying Genes.European urology open science · 2024Article
- Male Reproduction in Spinal Muscular Atrophy (SMA) and the Potential Impact of Oral Survival of Motor Neuron 2 (SMN2) Pre-mRNA Splicing Modifiers.Neurology and therapy · 2024Article
- Examining the trend of mortality of genitourinary system cancers in Babol, North Iran (2013-2021).BMC urology · 2024Article
- Novel mutation leading to splice donor loss in a conserved site ofJournal of medical genetics · 2024Article
- A Comparative Analysis of Orexins in the Physio-Pathological Processes of the Male Genital Tract: New Challenges? A Review.Veterinary sciences · 2024Review
- Downregulation of Serotonergic System Components in an Experimentally Induced Cryptorchidism in Rabbits.International journal of molecular sciences · 2024Article
- New insights on testicular cancer prevalence with novel diagnostic biomarkers and therapeutic approaches.Cancer reports (Hoboken, N.J.) · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by various genetic and developmental factors. While in some cases the association with genetic abnormalities and environmental causes has been shown, the etiology of cryptorchidism remains uncertain. Cryptorchidism is an established risk factor for infertility and testicular germ cell tumors (TGCT). Experimental animal models suggest a causative role for an abnormal testicular position on the disruption of spermatogenesis however the link between cryptorchidism and TGCT is less clear. The most common type of TGCT in cryptorchid testes is seminoma, believed to be derived from pluripotent prenatal germ cells. Recent studies have shown that seminoma cells and their precursor carcinoma in situ cells express a number of spermatogonial stem cell (SSC) markers suggesting that TGCTs might originate from adult stem cells. We review here the data on changes in the SSC somatic cell niche observed in cryptorchid testes of mouse models and in human patients. We propose that the misregulation of growth factors' expression may alter the balance between SSC self-renewal and differentiation and shift stem cells toward neoplastic transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.