ArticleMolecules (Basel, Switzerland)2012
Antifungal activity of Thymus vulgaris L. essential oil and its constituent phytochemicals against Rhizopus oryzae: interaction with ergosterol.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review.Frontiers in veterinary science · 2025Pooled it
- Chitosan nanoparticles loaded with ribavirin, carboplatin, and thyme oil downregulate SNQ2, ERG11, CDR1, and MDR1 in Candida strains.Scientific reports · 2025Article
- Effects of Spice Mixtures and Konjac Glucomannan-Whey Protein Isolate Based Edible Films on the Microbiological Stability and Textural Properties of Cheese.Foods (Basel, Switzerland) · 2025Article
- Surfactant-Driven Effects on the Antifungal Activity ofACS omega · 2025Article
- Vapor-Phase Essential Oils as Antifungal Agents againstFoods (Basel, Switzerland) · 2024Article
- A Review of Botanical Extracts with Repellent and Insecticidal Activity and Their Suitability for Managing Mosquito-Borne Disease Risk in Mexico.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Antifungal and genotoxic effects of Thymus serpyllum as a root canal irrigant.Clinical and experimental dental research · 2024Article
- Chemical Compositions of Essential Oil Extracted from Eight Thyme Species and Potential Biological Functions.Plants (Basel, Switzerland) · 2023Article
- Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole-thyme oil nanoemulsion for oral candidiasis.Drug delivery · 2023Article
- The significance of essential oils and their antifungal properties in the food industry: A systematic review.Heliyon · 2023Review
- Antimicrobial efficacy ofOpen veterinary journal · 2023Article
- Mode of Antifungal Action of Daito-Foods (Basel, Switzerland) · 2023Article
- Determination of Chemical Composition and Investigation of Biological Activities ofMolecules (Basel, Switzerland) · 2023Article
- Identification of lncRNA and weighted gene coexpression network analysis of germinatingMycology · 2023Article
- Non-Journal of fungi (Basel, Switzerland) · 2022Review
- Thymol Increases Sensitivity of Clinical Col-R Gram-Negative Bacteria to Colistin.Microbiology spectrum · 2022Article
- Essential Oils in Respiratory Mycosis: A Review.Molecules (Basel, Switzerland) · 2022Review
- In Vitro Effects of Lemon Balm Extracts in Reducing the Growth and Mycotoxins Biosynthesis ofToxins · 2022Article
- Diversity, antibacterial activity and chemical analyses of gut-associated fungi isolated from theFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucormycoses are emerging infections that have high rates of morbidity and mortality. They show high resistance to antifungal agents, and there is a limited therapeutic arsenal currently available, therefore, there is a great need to give priority to testing therapeutic agents for the treatment of mucormycosis. Along this line, the use of essential oils and phytoconstituents has been emphasized as a new therapeutic approach. The objective of this work was to investigate the antifungal activity of the essential oil (EO) of Thymus vulgaris, and its constituents thymol and p-cymene against Rhizopus oryzae, through microbiological screening, determination of minimal inhibitory concentration (MICs) and minimal fungicidal concentration (MFCs), effects on mycelial growth and germination of sporangiospores and interaction with ergosterol. The MIC of EO and thymol varied 128-512 µg/mL, but the MFC of EO and thymol varied 512-1024 µg/mL and 128-1024 µg/mL, respectively. The results also showed that EO and thymol significantly inhibited mycelial development and germination of sporangiospores. Investigation of the mechanism of antifungal action showed that EO and thymol interact with ergosterol. These data indicate that EO of T. vulgaris and thymol possess strong antifungal activity, which can be related to their interaction with ergosterol, supporting the possible use of these products in the treatment of mucormycosis.
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Registered trials
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