ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial lung pathogens, a mouse model study.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
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- Integrated Exhaled VOC and Clinical Biomarker Profiling for Predicting Bronchodilator Responsiveness in Asthma and COPD Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Early detection of bacterial pneumonia by characteristic induced odor signatures.BMC infectious diseases · 2024Article
- Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers.American journal of respiratory and critical care medicine · 2024Review
- Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art.Journal of pharmaceutical analysis · 2024Review
- Comparison of CuJournal of the American Society for Mass Spectrometry · 2024Article
- Identification of a marker of infection in the breath using a porcine pneumonia model.JTCVS open · 2023Article
- Non-invasive monitoring of microbiota and host metabolism using secondary electrospray ionization-mass spectrometry.Cell reports methods · 2023Article
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- Volatile Metabolites in Lavage Fluid Are Correlated with Cytokine Production in a Valley Fever Murine Model.Journal of fungi (Basel, Switzerland) · 2023Article
- Predominant SARS-CoV-2 variant impacts accuracy when screening for infection using exhaled breath vapor.Communications medicine · 2022Article
- Rapid detection ofiScience · 2022Article
- Differentiation of Cystic Fibrosis-Related Pathogens by Volatile Organic Compound Analysis with Secondary Electrospray Ionization Mass Spectrometry.Metabolites · 2021Article
- Pseudomonas aeruginosa Volatilome Characteristics and Adaptations in Chronic Cystic Fibrosis Lung Infections.mSphere · 2020Article
- Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry.Analytical and bioanalytical chemistry · 2019Article
- Breath metabolome of mice infected with Pseudomonas aeruginosa.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols.Analytica chimica acta · 2018Review
- Volatile fingerprinting of Pseudomonas aeruginosa and respiratory syncytial virus infection in an in vitro cystic fibrosis co-infection model.Journal of breath research · 2018Article
- Volatile fingerprinting of human respiratory viruses from cell culture.Journal of breath research · 2018Article
- Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath.Clinical mass spectrometry (Del Mar, Calif.) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial pneumonia is one of the leading causes of disease-related morbidity and mortality in the world, in part because the diagnostic tools for pneumonia are slow and ineffective. To improve the diagnosis success rates and treatment outcomes for bacterial lung infections, we are exploring the use of secondary electrospray ionization-mass spectrometry (SESI-MS) breath analysis as a rapid, noninvasive method for determining the etiology of lung infections in situ. Using a murine lung infection model, we demonstrate that SESI-MS breathprints can be used to distinguish mice that are infected with one of seven lung pathogens: Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae, representing the primary causes of bacterial pneumonia worldwide. After applying principal components analysis, we observed that with the first three principal components (primarily comprised of data from 14 peaks), all infections were separable via SESI-MS breathprinting (P < 0.0001). Therefore, we have shown the potential of this SESI-MS approach for rapidly detecting and identifying acute bacterial lung infections in situ via breath analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.