ArticleMarine drugs2013
Evaluation of macroalgae sulfated polysaccharides on the Leishmania (L.) amazonensis promastigote.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts.Marine drugs · 2021Review
- Photodynamic Therapy Using Toluidine Blue O (TBO) Dye as a Photosensitizer againstIranian journal of public health · 2021Article
- Anti-demodectic effects of okra eyelid patch inExperimental and therapeutic medicine · 2021Article
- Effect ofEthiopian journal of health sciences · 2021Article
- Extract of SeaweedFrontiers in pharmacology · 2021Article
- Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent.Molecular biology reports · 2020Article
- Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis.PLoS neglected tropical diseases · 2020Article
- Article
- Synthesis and evaluation of the antileishmanial activity of silver compounds containing imidazolidine-2-thione.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- 1,3-Bis(aryloxy)propan-2-ols as potential antileishmanial agents.Chemical biology & drug design · 2017Article
- Marine Algae as Source of Novel Antileishmanial Drugs: A Review.Marine drugs · 2017Review
- Nanostructured delivery systems with improved leishmanicidal activity: a critical review.International journal of nanomedicine · 2017Review
- In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures.Memorias do Instituto Oswaldo Cruz · 2015Article
- Overview on biological activities and molecular characteristics of sulfated polysaccharides from marine green algae in recent years.Marine drugs · 2014Review
- Anti-Leishmanial Activity of Artemisia persica,Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sulfated polysaccharides from Solieria filiformis (Sf), Botryocladia occidentalis (Bo), Caulerpa racemosa (Cr) and Gracilaria caudata (Gc) were extracted and extensively purified. These compounds were then subjected to in vitro assays to evaluate the inhibition of these polysaccharides on the growth of Leishmania (L.) amazonensis promastigotes. Under the same assay conditions, only three of the four sulfated polysaccharides were active against L. amazonensis, and the polysaccharide purified from Cr was the most potent (EC50 value: 34.5 μg/mL). The polysaccharides derived from Bo and Sf demonstrated moderate anti-leishmanial activity (EC50 values of 63.7 μg/mL and 137.4 μg/mL). In addition, we also performed in vitro cytotoxic assays toward peritoneal macrophages and J774 macrophages. For the in vitro cytotoxicity assay employing J774 cells, all of the sulfated polysaccharides decreased cell survival, with CC50 values of 27.3 μg/mL, 49.3 μg/mL, 73.2 μg/mL, and 99.8 μg/mL for Bo, Cr, Gc, and Sf, respectively. However, none of the sulfated polysaccharides reduced the cell growth rate of the peritoneal macrophages. These results suggest that macroalgae contain compounds with various chemical properties that can control specific pathogens. According to our results, the assayed sulfated polysaccharides were able to modulate the growth rate and cell survival of Leishmania (L.) amazonensis promastigotes in in vitro assays, and these effects involved the interaction of the sulfated polysaccharides on the cell membrane of the parasites.
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