ArticleCell death & disease2013
Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Latest Nanoparticles to Modulate Hypoxic Microenvironment in Photodynamic Therapy of Cervical Cancer: A Review of In Vivo Studies.International journal of molecular sciences · 2025Review
- Redox signaling-mediated tumor extracellular matrix remodeling: pleiotropic regulatory mechanisms.Cellular oncology (Dordrecht, Netherlands) · 2024Review
- Article
- ROS-Mediated Apoptosis and Autophagy in Ovarian Cancer Cells Treated with Peanut-Shaped Gold Nanoparticles.International journal of nanomedicine · 2021Article
- Nox4 regulates InsPThe EMBO journal · 2020Article
- Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[MedChemComm · 2018Article
- Microenvironment-Cell Nucleus Relationship in the Context of Oxidative Stress.Frontiers in cell and developmental biology · 2018Review
- Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats.Physiological reports · 2017Article
- Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer.Oncotarget · 2017Article
- NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.Leukemia · 2016Article
- MicroRNAs associated with the efficacy of photodynamic therapy in biliary tract cancer cell lines.International journal of molecular sciences · 2014Article
- Differential effect of artemisinin against cancer cell lines.Natural products and bioprospecting · 2014Article
- Copper-catalyzed aerobic aliphatic C-H oxygenation with hydroperoxides.Beilstein journal of organic chemistry · 2013Article
- Redox regulation in tumor cell epithelial-mesenchymal transition: molecular basis and therapeutic strategy.Signal transduction and targeted therapyReview
- Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.IEEE/ACM transactions on computational biology and bioinformaticsArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor metastasis is the main cause of death in cancer patients. Anoikis resistance is one critical malefactor of metastatic cancer cells to resist current clinical chemotherapeutic treatments. Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clinically employed due to their instability, complex synthesis procedure or low tumor cell selectivity. Herein, we describe a one-pot strategy to synthesize novel amino endoperoxides and their derivatives with good yields and stabilities. In vitro cell-based assays revealed that 4 out of the 14 amino endoperoxides selectively induce metastatic breast carcinoma cells but not normal breast cells to undergo apoptosis, in a dose-dependent manner. Mechanistic studies showed that the most potent amino endoperoxide, 4-Me, is selective for cancer cells expressing a high level of Nox4. The anticancer effects are further shown to be associated with reduced O2(-):H2O2 ratio and increased ·OH level in the cancerous cells. Animal study showed that 4-Me impairs orthotopic breast tumor growth as well as tumor cell metastasis to lymph nodes. Altogether, our study suggests that anticancer strategies that focus on redox-based apoptosis induction in tumors are clinically viable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.