ArticleFly
Asymmetric flies: the control of developmental noise in Drosophila.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster.Genetics · 2026Article
- Brain asymmetry is globally different in males and females: exploring cortical volume, area, thickness, and mean curvature.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Mother-Fetus Immune Cross-Talk Coordinates "Extrinsic"/"Intrinsic" Embryo Gene Expression Noise and Growth Stability.International journal of molecular sciences · 2022Article
- A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.Nature communications · 2022Article
- Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.Communications biology · 2020Article
- Article
- Making and breaking symmetry in development, growth and disease.Development (Cambridge, England) · 2019Review
- Mouse Skull Mean Shape and Shape Robustness Rely on Different Genetic Architectures and Different Loci.Frontiers in genetics · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Stressful conditions reveal decrease in size, modification of shape but relatively stable asymmetry in bumblebee wings.Scientific reports · 2018Article
- Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.PLoS genetics · 2018Article
- Quantitative Trait Loci and Antagonistic Associations for Two Developmentally Related Traits in the Drosophila Head.Journal of insect science (Online) · 2017Article
- Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.Journal of evolutionary biology · 2016Article
- Modularity and developmental stability in segmented animals: variation in translational asymmetry in geophilomorph centipedes.Development genes and evolution · 2016Article
- Regulation of Long Bone Growth in Vertebrates; It Is Time to Catch Up.Endocrine reviews · 2015Review
- Parental age influences developmental stability of the progeny in Drosophila.Proceedings. Biological sciences · 2015Article
- Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences.Journal of biosciences · 2015Review
- Fly wing vein patterns have spatial reproducibility of a single cell.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What are the sources of phenotypic variation and which factors shape this variation are fundamental questions of developmental and evolutionary biology. Despite this simple formulation and intense research, controversy remains. Three points are particularly discussed: (1) whether adaptive developmental mechanisms buffering variation exist at all; (2) if yes, do they involve specific genes and processes, i.e., different from those involved in the development of the traits that are buffered?; and (3) whether different mechanisms specifically buffer the various sources of variation, i.e., genetic, environmental and stochastic, or whether a generalist process buffers them all at once. We advocate that experimental work integrating different levels of analysis will improve our understanding of the origin of phenotypic variation and thus help answering these contentious questions. In this paper, we first survey the current views on these issues, highlighting potential sources of controversy. We then focus on the stochastic part of phenotypic variation, as measured by fluctuating asymmetry, and on current knowledge about the genetic basis of developmental stability. We report our recent discovery that an individual gene, Cyclin G, plays a central role-adaptive or not-in developmental stability in Drosophila. ( 1) We discuss the implications of this discovery on the regulation of organ size and shape, and finally point out open questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.