ReviewFrontiers in neural circuits2013
CREB and neuronal selection for memory trace.
Review in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Neuronal allocation and sparse coding of episodic memories in the human hippocampus.Scientific reports · 2025Article
- Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice.Cell · 2025Article
- PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise.Frontiers in pharmacology · 2025Review
- An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways.Biomedicines · 2023Review
- Hypothesis on ontogenesis and pathophysiology of Alzheimer's disease.Einstein (Sao Paulo, Brazil) · 2022Review
- Potential evidence of peripheral learning and memory in the arms of dwarf cuttlefish, Sepia bandensis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- Review
- Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Fisetin Prevents HT22 Cells From High Glucose-Induced NeurotoxicityFrontiers in neuroscience · 2020Article
- Acute Exercise Intensity and Memory Function: Evaluation of the Transient Hypofrontality Hypothesis.Medicina (Kaunas, Lithuania) · 2019Article
- Neuroepigenetic mechanisms underlying fear extinction: emerging concepts.Psychopharmacology · 2019Review
- PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.BMC neuroscience · 2018Article
- Transcriptional Regulation Involved in Fear Memory Reconsolidation.Journal of molecular neuroscience : MN · 2018Review
- Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability.Nature neuroscience · 2018Review
- Growth hormone biases amygdala network activation after fear learning.Translational psychiatry · 2016Article
- Which Neurons Will Be the Engram - Activated Neurons and/or More Excitable Neurons?Experimental neurobiology · 2016Review
- Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1-42-Induced Mouse Model of Alzheimer's Disease.PloS one · 2016Article
- The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor.Frontiers in neuroscience · 2016Article
- Watching a memory form-VSD imaging reveals a novel memory mechanism.Communicative & integrative biology · 2016Article
- Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats.Behavioral and brain functions : BBF · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite considerable progress over the past several decades, our understanding of the mechanisms underlying memory encoding, storage, and expression in a complex neural network are far from complete. In particular, how some neurons rather than others are selectively engaged to encode memory remains largely unknown. Using virus-mediated gene delivery into a small subset of neurons in a given network, molecular imaging of neuronal activity, pharmacological perturbation of specific neurons' activity and animal behavior assays, recent studies have begun to provide insight into molecular and cellular mechanisms responsible for the selection of neurons for inclusion into a memory trace. Here, we focus on a review of recent findings supporting the hypothesis that the level of the transcription factor CREB (cAMP/Ca(2+)-response element binding protein) is a key factor governing which neurons are recruited to a given memory trace. These recent findings open a new perspective on memory trace at the neural circuit level and also raise many important questions. Future studies employing more advanced neurobiological techniques for targeting defined populations of neurons and manipulating their activity in time and space in a complex neural network will give answers to these newly emerging questions and extend our understanding of the neurobiological basis of the memory trace.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.