ArticleBritish journal of cancer2013
Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer.Science advances · 2026Article
- Small cell lung cancer with liver metastases: from underlying mechanisms to treatment strategies.Cancer metastasis reviews · 2024Review
- Involvement of Epithelial-Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity.Cancers · 2023Article
- Development of a small cell lung cancer organoid model to study cellular interactions and survival after chemotherapy.Frontiers in pharmacology · 2023Article
- Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.The Journal of clinical endocrinology and metabolism · 2022Article
- Rare deleterious germline variants and risk of lung cancer.NPJ precision oncology · 2021Article
- Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D.Endocrinology · 2019Article
- Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.Molecular metabolism · 2018Article
- Metabolic signatures of four major histological types of lung cancer cells.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Effect of A549 neuroendocrine differentiation on cytotoxic immune response.Endocrine connections · 2018Article
- Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans.Journal of the Endocrine Society · 2017Article
- Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers.Cell adhesion & migration · 2017Article
- Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans.American journal of physiology. Endocrinology and metabolism · 2017Article
- Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo.PloS one · 2016Article
- Novel therapies in small cell lung cancer.Translational lung cancer research · 2015Review
- Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.American journal of physiology. Endocrinology and metabolism · 2015Article
- Positive expression of pro-opiomelanocortin (POMC) is a novel independent poor prognostic marker in surgically resected non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Clinical utility of plasma POMC and AgRP measurements in the differential diagnosis of ACTH-dependent Cushing's syndrome.The Journal of clinical endocrinology and metabolism · 2014Article
- Continuous 24-hour leptin, proopiomelanocortin, and amino acid measurements in human cerebrospinal fluid: correlations with plasma leptin, soluble leptin receptor, and amino acid levels.The Journal of clinical endocrinology and metabolism · 2014Article
- Sodium Valproate Inhibits Small Cell Lung Cancer Tumor Growth on the Chicken Embryo Chorioallantoic Membrane and Reduces the p53 and EZH2 Expression.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSmall-cell lung cancer (SCLC) has a very aggressive clinical course with early metastasis. This study investigated how the distinctive neuroendocrine characteristics contribute to disease progression and invasion in human SCLC.
methodsThe neuroendocrine phenotype (pro-opiomelanocortin (POMC)) was quantified by ELISA in blood samples from 43 SCLC patients. The neuroendocrine (POMC, chromogranin A, neuron-specific enolase, NCAM) and epithelial (cytokeratin and E-cadherin) phenotypes were investigated, using ELISA and immunocytochemistry/immunohistochemistry.
resultsIn SCLC patients, 16% had elevated circulating POMC, which was associated with significantly worse survival (P=0.02) and liver metastases (P=0.004). In addition, POMC correlated with epithelial-positive circulating tumour cells (P=0.0002). In a panel of SCLC cell lines, all POMC-secreting cell lines expressed cytokeratin (40% of total). Even after cloning, DMS 79 cells expressed both neuroendocrine and epithelial markers. DMS 79 xenografts secreted POMC into the blood, which mirrored the tumour volume. These xenografts expressed both neuroendocrine and epithelial phenotypes in all tumours, with both phenotypes prevalent in cells invading the surrounding tissue.
conclusionBoth neuroendocrine and epithelial phenotypes coexist in human SCLC tumours in vitro and in vivo and this persists in invading tumour cells. In patients, POMC secretion predicts poor survival and liver metastases, suggesting a crucial role of the neuroendocrine phenotype.
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