ArticleDisease models & mechanisms2013
Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice.
Article in Disease models & mechanisms, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.Pediatric nephrology (Berlin, Germany) · 2024Guideline
- Urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric vesicoureteral reflux patients.Pediatric nephrology (Berlin, Germany) · 2026Article
- Single-nucleus transcriptomics illuminates sex differences during murine Escherichia coli pyelonephritis.Communications biology · 2026Article
- Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenicProceedings of the National Academy of Sciences of the United States of America · 2022Article
- A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection.Biology open · 2021Article
- Sex Differences in Population Dynamics during Formation of Kidney Bacterial Communities by Uropathogenic Escherichia coli.Infection and immunity · 2021Article
- Metabolic acidosis exacerbates pyelonephritis in mice prone to vesicoureteral reflux.Physiological reports · 2020Article
- The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2020Review
- Ribonuclease 7 Shields the Kidney and Bladder from Invasive UropathogenicJournal of the American Society of Nephrology : JASN · 2019Article
- Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.The Journal of clinical investigation · 2018Article
- Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.Kidney international · 2018Article
- Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis.Disease models & mechanisms · 2017Article
- Murine model indicates 22q11.2 signaling adaptorProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Renal development in the fetus and premature infant.Seminars in fetal & neonatal medicine · 2017Review
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Inflammation drives renal scarring in experimental pyelonephritis.American journal of physiology. Renal physiology · 2017Article
- New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon.BMC nephrology · 2016Article
- Androgens Enhance Male Urinary Tract Infection Severity in a New Model.Journal of the American Society of Nephrology : JASN · 2016Article
- Complete Genome Sequence of Uropathogenic Escherichia coli Strain CI5.Genome announcements · 2015Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Vesicoureteric reflux (VUR) is a common congenital defect of the urinary tract that is usually discovered after a child develops a urinary tract infection. It is associated with reflux nephropathy, a renal lesion characterized by the presence of chronic tubulointersitial inflammation and fibrosis. Most patients are diagnosed with reflux nephropathy after one or more febrile urinary tract infections, suggesting a potential role for infection in its development. We have recently shown that the C3H mouse has a 100% incidence of VUR. Here, we evaluate the roles of VUR and uropathogenic Escherichia coli infection in the development of reflux nephropathy in the C3H mouse. We find that VUR in combination with sustained kidney infection is crucial to the development of reflux nephropathy, whereas sterile reflux alone fails to induce reflux nephropathy. A single bout of kidney infection without reflux fails to induce reflux nephropathy. The host immune response to infection was examined in two refluxing C3H substrains, HeN and HeJ. HeJ mice, which have a defect in innate immunity and bacterial clearance, demonstrate more significant renal inflammation and reflux nephropathy compared with HeN mice. These studies demonstrate the crucial synergy between VUR, sustained kidney infection and the host immune response in the development of reflux nephropathy in a mouse model of VUR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.