ArticleThe Pediatric infectious disease journal2013
Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Randomised trial of azithromycin to eradicateArchives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Research progress on risk factors and clinical management ofFrontiers in pediatrics · 2026Review
- Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children.Scientific reports · 2024Article
- Predicting the likelihood of lower respiratory tractArchives of disease in childhood. Fetal and neonatal edition · 2023Article
- Verification of immunology-related genetic associations in BPD supports ABCA3 and five other genes.Pediatric research · 2022Article
- Polymorphisms of fibronectin-1 (rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655) are not associated with bronchopulmonary dysplasia in preterm infants.Molecular and cellular biochemistry · 2022Article
- Bronchopulmonary dysplasia: how can we improve its outcomes?Korean journal of pediatrics · 2019Article
- PerinatalFrontiers in cellular and infection microbiology · 2019Article
- Ureaplasma isolates stimulate pro-inflammatory CC chemokines and matrix metalloproteinase-9 in neonatal and adult monocytes.PloS one · 2018Article
- Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia.The Journal of pediatrics · 2017Article
- Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model.PloS one · 2016Article
- Role of Ureaplasma Respiratory Tract Colonization in Bronchopulmonary Dysplasia Pathogenesis: Current Concepts and Update.Clinics in perinatology · 2015Review
- Genetic predisposition to bronchopulmonary dysplasia.Seminars in perinatology · 2015Review
- Animal models of bronchopulmonary dysplasia. The preterm baboon models.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease.Antioxidants & redox signaling · 2014Review
- Immune profiling of BALB/C and C57BL/6 mice reveals a correlation between Ureaplasma parvum-Induced fetal inflammatory response syndrome-like pathology and increased placental expression of TLR2 and CD14.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
- Association of TLR6 single nucleotide polymorphisms and clinical features of ischemic stroke in Korean population.Journal of exercise rehabilitation · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundUreaplasma spp. respiratory tract colonization is a risk factor for bronchopulmonary dysplasia (BPD) in preterm infants, but differences in host susceptibility have not been elucidated. We hypothesized that variants in genes regulating the innate immune response are associated with altered risk for Ureaplasma spp. respiratory colonization and BPD in preterm infants.
methodsTwenty-four tag single nucleotide polymorphisms (SNPs) from Toll-like receptor (TLR)1, TLR2, TLR4 and TLR6 were assayed in 298 infants <33 weeks gestation who had serial respiratory cultures for Ureaplasma spp. and were evaluated for BPD.
resultsThe majority of subjects (N = 205 [70%]) were African-American. One hundred ten (37%) were Ureaplasma positive. Four SNPs in TLR2 and TLR6 were significantly associated with Ureaplasma respiratory tract colonization. Single SNPs in TLR2, TLR4 and TLR6 were associated with BPD. TLR6 SNP rs5743827 was associated with both a decreased risk for Ureaplasma respiratory tract colonization and decreased risk for BPD (odds ratio: 0.54 [0.34-0.86] and odds ratio: 0.54 [0.31-0.95], respectively). There was a significant additive interaction between Ureaplasma colonization and genotype at TLR6 SNP rs5743827 (Padditive = 0.023), with an attributable proportion due to interaction of 0.542.
conclusionsPolymorphisms in host defense genes may alter susceptibility to Ureaplasma infection and severity of the inflammatory response contributing to BPD. These observations implicate host genetic susceptibility as a major factor in BPD pathogenesis in Ureaplasma-infected preterms.
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