ArticleFrontiers in molecular neuroscience2013
Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches.
Article in Frontiers in molecular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of Supramolecular Interactions on E/Z-Isomerizations in Water and Their Importance for Biological Applications.Archiv der Pharmazie · 2026Review
- Multimodal Photoswitchable Modulation of Insect Glutamatergic Transmission by Quaternary Ammonium Azobenzenes.ACS omega · 2026Article
- Ion Channel-Targeting Toxins: Structural Mechanisms of Activation, Inhibition, and Therapeutic Potential.Toxins · 2025Review
- Installation of cationic phosphorus on dimethyldihydropyrene photoswitches: expanding the atomic repertoire towards far-red photoswitching in water.Chemical science · 2025Article
- Looking for a Beam of Light to Heal Chronic Pain.Journal of pain research · 2024Review
- Effect of stacking interactions on charge transfer states in photoswitches interacting with ion channels.Physical chemistry chemical physics : PCCP · 2023Article
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals.Nature communications · 2023Article
- Advances and opportunities in the exciting world of azobenzenes.Nature reviews. Chemistry · 2022Review
- Azobenzene/Tetraethyl Ammonium Photochromic Potassium Channel Blockers: Scope and Limitations for Design of Para-Substituted Derivatives with Specific Absorption Band Maxima and Thermal Isomerization Rate.International journal of molecular sciences · 2021Article
- Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal.International journal of molecular sciences · 2021Review
- Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis.Micromachines · 2020Review
- Reversible Photocontrolled Nanopore Assembly.Journal of the American Chemical Society · 2019Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes.Bioscience reports · 2019Article
- Restoring Vision to the Blind with Chemical Photoswitches.Chemical reviews · 2018Review
- Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.British journal of pharmacology · 2018Article
- Photopharmacological control of bipolar cells restores visual function in blind mice.The Journal of clinical investigation · 2017Article
- Synapses in the spotlight with synthetic optogenetics.EMBO reports · 2017Review
- Serotonin modulates spike probability in the axon initial segment through HCN channels.Nature neuroscience · 2016Article
- Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes.PloS one · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Ion channels are transmembrane proteins that control the movement of ions across the cell membrane. They are the molecular machines that make neurons excitable by enabling the initiation and propagation of action potentials (APs). Rapid signaling within and between neurons requires complex molecular processes that couple the sensing of membrane voltage or neurotransmitter release to the fast opening and closing of the ion channel gate. Malfunction of an ion channel's sensing or gating module can have disastrous pathological consequences. However, linking molecular changes to the modulation of neural circuits and ultimately to a physiological or pathological state is not a straightforward task. It requires precise and sophisticated methods of controlling the function of ion channels in their native environment. To address this issue we have developed new photochemical tools that enable the remote control of neuronal ion channels with light. Due to its optical nature, our approach permits the manipulation of the nervous system with high spatial, temporal and molecular precision that will help us understand the link between ion channel function and physiology. In addition, this strategy may also be used in the clinic for the direct treatment of some neuronal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.