ReviewClinical schizophrenia & related psychoses2014
Schizophrenia: a systemic disorder.
Review in Clinical schizophrenia & related psychoses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis.Schizophrenia research · 2017Pooled it
- The impact of mental health disorders in pregnancy on obstetric and neonatal outcomes: A narrative review.Brain, behavior, & immunity - health · 2026Review
- Birth seasonality and height in patients with schizophrenia: a multi-institutional cohort study.European archives of psychiatry and clinical neuroscience · 2026Article
- Impact of severe anxiety, depression, and their comorbidity on glucose metabolism in first-episode antipsychotic-naïve schizophrenia patients.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Exploring interrelationships between cognition, functioning and quality of life in schizophrenia spectrum disorders: a Bayesian analysis of networks.European archives of psychiatry and clinical neuroscience · 2026Article
- Deep Learning-Based Structural Brain Age Estimation in Bipolar Disorder and Schizophrenia: A Single-Site Pilot Study.Human brain mapping · 2026Article
- Antipsychotic treatment patterns and cardiometabolic medicine use: current real-world evidence.Epidemiology and psychiatric sciences · 2026Article
- Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes.Molecular psychiatry · 2025Review
- High-density lipoprotein is inversely associated with psychiatric symptoms across diagnoses in patients with general psychiatric disorders.Frontiers in psychiatry · 2025Article
- Effects of aerobic training on brain architecture, hippocampal volume, cardiorespiratory parameters, and health-related quality of life among patients with schizophrenia: A systematic review.Indian journal of psychiatry · 2024Review
- Multimorbidity in Severe Mental Illness as Part of the Neurodevelopmental Continuum: Physical Health-Related Endophenotypes of Schizophrenia-A Narrative Review.Brain sciences · 2024Review
- Optical Coherence Tomography in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.Biological psychiatry global open science · 2024Article
- An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth.Schizophrenia research · 2022Article
- Are Essential Trace Elements Effective in Modulation of Mental Disorders? Update and Perspectives.Biological trace element research · 2022Review
- A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders.Clinical microbiology reviews · 2022Review
- Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis.BMC psychiatry · 2018Article
- The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.Frontiers in psychiatry · 2017Review
- Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity.Translational psychiatry · 2016Review
- Microvascular dysfunction in schizophrenia: a case-control study.NPJ schizophrenia · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The concept of schizophrenia that is most widely taught is that it is a disorder in which psychotic symptoms are the main problem, and a dysregulation of dopamine signaling is the main feature of pathophysiology. However, this concept limits clinical assessment, the treatments offered to patients, research, and the development of therapeutics. A more appropriate conceptual model is that: 1) schizophrenia is not a psychotic disorder, but a disorder of essentially every brain function in which psychosis is present; 2) it is not a brain disease, but a disorder with impairments throughout the body; 3) for many patients, neuropsychiatric problems other than psychosis contribute more to impairment in function and quality of life than does psychosis; and, 4) some conditions that are considered to be comorbid are integral parts of the illness. In conclusion, students, patients, and family members should be taught this model, along with its implications for assessment, research, and therapeutics.
Indexed as
Identifiers
23518782PMC4390134W2322674564What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.