ArticleFrontiers in immunology2013
Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism.Mucosal immunology · 2026Article
- Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair.Cell reports · 2025Article
- Examination of Horizontal Transmission ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- IL-27 Enhances γδ T Cell-Mediated Innate Resistance to Primary Hookworm Infection in the Lungs.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Assessment of faithful interleukin-3 production by novel bicistronic interleukin-3 reporter mice.Immunology letters · 2020Article
- Intestinal helminth infection promotes IL-5- and CD4Mucosal immunology · 2019Article
- Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection.PLoS neglected tropical diseases · 2017Article
- IL-17RBAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.Molecular & cellular proteomics : MCP · 2014Article
- Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.Nature immunology · 2014Article
- Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.Seminars in immunology · 2014Review
- Systemic impact of intestinal helminth infections.Mucosal immunology · 2014Review
- Immunity to gastrointestinal nematodes: mechanisms and myths.Immunological reviews · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salient features of parasitic worm infection, including parasite development through sequential larval stages as it migrates through specific tissue sites. Immune competent hosts respond to infection by N. brasiliensis with a rapid and selective development of a profound Th2 immune response that appears able to confer life long protective immunity against reinfection. This review details how the lung can be the site of migrating nematode immune killing and the gut a site of rapid immune mediated clearance of worms. Furthermore it appears that N. brasiliensis induced responses in the lung are sufficient for conferring immunity in lung and gut while infection of the gut only confers immunity in the gut. This review also covers the role of IL-4, STAT6, and the innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin in the generation of CD4-mediated immunity against N. brasiliensis reinfection and discusses what cytokines might be involved in mediated killing or expulsion of helminth parasites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.