ArticleClinical immunology (Orlando, Fla.)2013
Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease.
Article in Clinical immunology (Orlando, Fla.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Potassium-Rich, Gluten-Free Diets for Patients with Sjögren's Syndrome: A Mini-ReviewEndocrine, metabolic & immune disorders drug targets · 2026Review
- Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine.Nature communications · 2022Article
- Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review.Molecules (Basel, Switzerland) · 2019Review
- Molecular characteristics of rhesus macaque interleukin-22: cloning, in vitro expression and biological activities.Immunology · 2018Article
- Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells.Seminars in immunopathology · 2018Review
- Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease.Frontiers in immunology · 2018Article
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- The effects of reduced gluten barley diet on humoral and cell-mediated systemic immune responses of gluten-sensitive rhesus macaques.Nutrients · 2015Article
- Interleukin-22: immunobiology and pathology.Annual review of immunology · 2015Review
- Celiac and Non-Celiac Forms of Gluten Sensitivity: Shifting Paradigms of an Old Disease.British microbiology research journal · 2013Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Celiac disease (CD) is an autoimmune disorder caused by intolerance to dietary gluten. The interleukin (IL)-17 and IL-22 function as innate regulators of mucosal integrity. Impaired but not well-understood kinetics of the IL-17/22 secretion was described in celiac patients. Here, the IL-17 and IL-22-producing intestinal cells were studied upon their in vitro stimulation with mitogens in class II major histocompatibility complex-defined, gluten-sensitive rhesus macaques. Pediatric biopsies were collected from distal duodenum during the stages of disease remission and relapse. Regardless of dietary gluten content, IL-17 and IL-22-producing cells consisted of CD4+ and CD8+ T lymphocytes as well as of lineage-negative (Lin-) cells. Upon introduction of dietary gluten, capability of intestinal T cells to secrete IL-17/22 started to decline (p<0.05), which was paralleled with gradual disruption of epithelial integrity. These data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
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