ArticleEuropean journal of medicinal chemistry2013
Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
Article in European journal of medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- The enhanced ultrafast dissociation ofRSC advances · 2025Article
- Green electrosynthesis of bis(indolyl)methane derivatives in deep eutectic solvents.BMC chemistry · 2024Article
- LiORSC advances · 2024Article
- Exploring hydrophilic 2,2-di(indol-3-yl)ethanamine derivatives against Leishmania infantum.PloS one · 2024Article
- PolyaromaticMolecules (Basel, Switzerland) · 2023Article
- Design, synthesis, and biological evaluation of 3,3'-diindolylmethaneRSC medicinal chemistry · 2023Article
- Evaluation of the Anti-Biomedicines · 2022Article
- Anti-Virulence Activity of 3,3'-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing Benefits.Pharmaceutics · 2022Article
- Effective Synthesis and Biological Evaluation of Natural and Designed Bis(indolyl)methanes via Taurine-Catalyzed Green Approach.ACS omega · 2022Article
- Phenotype Screening of an Azole-bisindole Chemical Library Identifies URB1483 as a New Antileishmanial Agent Devoid of Toxicity on Human Cells.ACS omega · 2021Article
- Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis.Molecules (Basel, Switzerland) · 2021Article
- Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids.Molecular diversity · 2021Article
- Article
- Crystal structure and Hirshfeld analysis of 2-[bis-(1-methyl-1Acta crystallographica. Section E, Crystallographic communications · 2018Article
- Article
- Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
13 authors.
Funding
Abstract
An efficient protocol for synthesis of 3,3'-diindolylmethanes using recyclable Fe-pillared interlayered clay (Fe-PILC) catalyst under aqueous medium has been developed. All synthesized 3,3'-diindolylmethanes showed promising antileishmanial activity against Leishmania donovani promastigotes as well as axenic amastigotes. Structure-activity relationship analysis revealed that nitroaryl substituted diindolylmethanes showed potent antileishmanial activity. The 4-nitrophenyl linked 3,3'-diindolylmethane 8g was found to be the most potent antileishmanial analog showing IC50 values of 7.88 and 8.37 μM against both L. donovani promastigotes and amastigotes, respectively. Further, a pharmacophore based QSAR model was established to understand the crucial molecular features of 3,3'-diindolylmethanes essential for potent antileishmanial activity. These compounds also exhibited promising antifungal activity against Cryptococcus neoformans, wherein fluorophenyl substituted 3,3'-diindolylmethanes were found to be most potent antifungal agents. Developed synthetic protocol will be useful for economical and eco-friendly synthesis of potent antileishmanial and antifungal 3,3'-diindolylmethane class of compounds.
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