ArticleScandinavian journal of trauma, resuscitation and emergency medicine2013
Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis.Bioengineering (Basel, Switzerland) · 2023Article
- Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model.Frontiers in physiology · 2022Article
- Application of Piezo-Based Measuring System for Evaluation of Nucleic Acid-Based Drugs Influencing the Coagulation.Sensors (Basel, Switzerland) · 2019Article
- The Effect of Ex Vivo Factor XIII Supplementation on Clot Formation in Blood Samples From Cardiac and Scoliosis Surgery Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
- Article
- Comparison of fibrin-based clot elasticity parameters measured by free oscillation rheometry (ReoRox ®) versus thromboelastometry (ROTEM ®).Scandinavian journal of clinical and laboratory investigation · 2015Article
- Assays of different aspects of haemostasis - what do they measure?Thrombosis journal · 2015Article
- Correction of hypothermic and dilutional coagulopathy with concentrates of fibrinogen and factor XIII: an in vitro study with ROTEM.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
backgroundHaemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. Fibrinogen concentrate can correct dilutional coagulopathy and has an additional effect when combined with factor XIII concentrate. However, their effect on dilutional coagulopathy concomitant with hypothermia has not been studied previously. Free oscillation rheometry - FOR (Reorox®) - is a novel viscoelastic haemostatic assay that has not been studied in this context before.
methodsBlood from 10 healthy volunteers was diluted by 33% with hydroxyethyl starch or Ringer's acetate solutions. Effects of fibrinogen added in vitro with and without factor XIII were studied at 33°C and 37°C. Coagulation velocity (coagulation time) and clot strength (elasticity) were assessed with FOR. Coagulation was initiated in vitro with thromboplastin alone, or thromboplastin plus a platelet inhibitor.
resultsHydroxyethyl starch increased the coagulation time and decreased clot strength significantly more than Ringer's acetate solution, both in the presence and absence of a platelet inhibitor. There was a significant interaction between haemodilution with hydroxyethyl starch and hypothermia, resulting in increased coagulation time. After addition of fibrinogen, coagulation time shortened and elasticity increased, with the exception of fibrinogen-dependent clot strength (i.e., elasticity in the presence of a platelet inhibitor) after hydroxyethyl starch haemodilution. Factor XIII had an additional effect with fibrinogen on fibrinogen-dependent clot strength in blood diluted with Ringer's acetate solution. Hypothermia did not influence any of the coagulation factor effects.
conclusionsBoth haemodilution and mild hypothermia impaired coagulation. Coagulopathy was more pronounced after haemodilution with hydroxyethyl starch than with Ringer's acetate. Addition of fibrinogen with factor XIII was unable to reverse hydroxyethyl starch induced clot instability, but improved coagulation in blood diluted with Ringer's acetate solution. Fibrinogen improved coagulation irrespective of hypothermia.
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