SynthesisCanadian journal of surgery. Journal canadien de chirurgie2013
Intentionally curative treatment of locally recurrent rectal cancer: a systematic review.
Synthesis in Canadian journal of surgery. Journal canadien de chirurgie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Lateral pelvic lymphadenectomy for low rectal cancer: a META-analysis of recurrence rates.International journal of colorectal disease · 2021Pooled it
- Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer.International journal of clinical oncology · 2020Guideline
- Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma.The Cochrane database of systematic reviews · 2018Pooled it
- Current clinical practice of radiotherapy for the non-operative treatment of patients with unresectable locally recurrent rectal cancer: results of a national survey of the dutch society for radiotherapy and oncology.Radiation oncology (London, England) · 2026Article
- Detecting cancer recurrence in general practice: a Danish national cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Neoadjuvant chemo-reirradiation followed by resection and intraoperative electron beam radiotherapy: outcomes of multimodality treatment for locally recurrent rectal cancer.Radiation oncology (London, England) · 2025Article
- Oncological outcomes of planned and unplanned low Hartmann's procedure and restorative low anterior resection for rectal cancer: a population-based cross-sectional study.Techniques in coloproctology · 2025Observational
- Multidisciplinary approach to target volume delineation in locally recurrent rectal cancer: An explorative study.Clinical and translational radiation oncology · 2025Article
- Association of Pelvic Structure Involvement and Tumor Morphology at MRI with Prognosis Following Resection in Locally Recurrent Rectal Cancer.Radiology. Imaging cancer · 2025Observational
- Prospective radiotherapy quality Assurance leads to delineation guideline refinements for recurrent rectal cancer: Experience from the PelvEx II study.Clinical and translational radiation oncology · 2025Article
- Current Management of Locally Recurrent Rectal Cancer.Cancers · 2024Review
- Short-term and long-term outcomes of laparoscopic surgery for locally recurrent rectal cancer: a propensity score-matched cohort study.Techniques in coloproctology · 2024Article
- Post-operative complications following dose adaptation of intra-operative electron beam radiation therapy in locally advanced or recurrent rectal cancer.Journal of contemporary brachytherapy · 2024Article
- Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach.Journal of contemporary brachytherapy · 2024Article
- TORCH-R trial protocol: hypofractionated radiotherapy combined with chemotherapy and toripalimab for locally recurrent rectal cancer: a prospective, single-arm, two-cohort, phase II trial.Frontiers in oncology · 2023Article
- Defining early recurrence of locally recurrent rectal cancer.American journal of cancer research · 2022Article
- Reevaluating the Evidence for Intensive Postoperative Extracolonic Surveillance for Nonmetastatic Colorectal Cancer.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022Article
- [Should neoadjuvant chemoradiation be combined with regional hyperthermia for rectal cancer?]Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Article
- Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway.Aging · 2021Article
- Re-Irradiation in Patients with Recurrent Rectal Cancer is Safe and Feasible.Annals of surgical oncology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a lack of outcome data beyond local recurrence rates after primary treatment in rectal cancer, despite more information being necessary for clinical decision-making. We sought to determine patient selection, therapeutic modalities and outcomes of locally recurrent rectal cancer treated with curative intent.
methodsWe searched MEDLINE (1990-2010) using the medical subject headings "rectal neoplasms" and "neoplasm recurrence, local." Selection of cohort studies was based on the primary intention of treatment and availability of at least 1 outcome variable.
resultsWe included 55 cohort studies comprising 3767 patients; 8 studies provided data on the rate of intentionally curative treatment from an unselected consecutive cohort of patients (481 of 1188 patients; 40%). Patients were symptomatic with pain in 50% (796 of 1607) of cases. Overall, 3088 of 3767 patients underwent resection. The R0 resection rate was 56% (1484 of 2637 patients). The rate of external beam radiotherapy was 100% in 9 studies, 0% in 5 studies, and ranged from 12% to 97% in 37 studies. Overall postoperative mortality was 2.2% (57 of 2515 patients). Five-year survival was at least 25%, with an upper limit of 41% in 11 of 18 studies including at least 50 resections. We found a significant increase in reported survival rates over time (r2 = 0.214, p = 0.007).
conclusionMore uniformity in treatment protocols and reporting on outcomes for locally recurrent rectal cancer is warranted. The observed improvement of reported survival rates in time is probably related to better patient selection and optimized multimodality treatment in specialized centres.
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